Gut microbiota markers associated with obesity and overweight in Italian adults

Abstract In the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI = 36.6 ± 6.0; F/M = 40/6) was analyzed and compared...

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Autores principales:	Vanessa Palmas, Silvia Pisanu, Veronica Madau, Emanuela Casula, Andrea Deledda, Roberto Cusano, Paolo Uva, Sarah Vascellari, Andrea Loviselli, Aldo Manzin, Fernanda Velluzzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11438df90bd04dbc9713709fbb71bc0a
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spelling	oai:doaj.org-article:11438df90bd04dbc9713709fbb71bc0a2021-12-02T15:53:43ZGut microbiota markers associated with obesity and overweight in Italian adults10.1038/s41598-021-84928-w2045-2322https://doaj.org/article/11438df90bd04dbc9713709fbb71bc0a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84928-whttps://doaj.org/toc/2045-2322Abstract In the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI = 36.6 ± 6.0; F/M = 40/6) was analyzed and compared to that of 46 NW subjects (BMI = 21.6 ± 2.1; F/M = 41/5), matched for sex, age and smoking status, by using 16S rRNA gene sequencing on MiSeq Illumina platform. The gut microbial community of OB patients exhibited a significant decrease in the relative abundance of several Bacteroidetes taxa (i.e. Flavobacteriaceae, Porphyromonadaceae, Sphingobacteriaceae, Flavobacterium, Rikenella spp., Pedobacter spp., Parabacteroides spp., Bacteroides spp.) when compared to NW; instead, several Firmicutes taxa were significantly increased in the same subjects (Lachnospiraceae, Gemellaceae, Paenibacillaceae, Streptococcaceae, Thermicanaceae, Gemella, Mitsuokella, Streptococcus, Acidaminococcus spp., Eubacterium spp., Ruminococcus spp., Megamonas spp., Streptococcus, Thermicanus, Megasphaera spp. and Veillonella spp.). Correlation analysis indicated that body fatness and waist circumference negatively correlated with Bacteroidetes taxa, while Firmicutes taxa positively correlated with body fat and negatively with muscle mass and/or physical activity level. Furthermore, the relative abundance of several bacterial taxa belonging to Enterobacteriaceae family, known to exhibit endotoxic activity, was increased in the OB group compared to NW. The results extend our knowledge on the GM profiles in Italian OB, identifying novel taxa linking obesity and intestine.Vanessa PalmasSilvia PisanuVeronica MadauEmanuela CasulaAndrea DeleddaRoberto CusanoPaolo UvaSarah VascellariAndrea LoviselliAldo ManzinFernanda VelluzziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vanessa Palmas Silvia Pisanu Veronica Madau Emanuela Casula Andrea Deledda Roberto Cusano Paolo Uva Sarah Vascellari Andrea Loviselli Aldo Manzin Fernanda Velluzzi Gut microbiota markers associated with obesity and overweight in Italian adults
description	Abstract In the present study, we characterized the distinctive signatures of the gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both of Sardinian origin. Fecal bacterial composition of 46 OB patients (BMI = 36.6 ± 6.0; F/M = 40/6) was analyzed and compared to that of 46 NW subjects (BMI = 21.6 ± 2.1; F/M = 41/5), matched for sex, age and smoking status, by using 16S rRNA gene sequencing on MiSeq Illumina platform. The gut microbial community of OB patients exhibited a significant decrease in the relative abundance of several Bacteroidetes taxa (i.e. Flavobacteriaceae, Porphyromonadaceae, Sphingobacteriaceae, Flavobacterium, Rikenella spp., Pedobacter spp., Parabacteroides spp., Bacteroides spp.) when compared to NW; instead, several Firmicutes taxa were significantly increased in the same subjects (Lachnospiraceae, Gemellaceae, Paenibacillaceae, Streptococcaceae, Thermicanaceae, Gemella, Mitsuokella, Streptococcus, Acidaminococcus spp., Eubacterium spp., Ruminococcus spp., Megamonas spp., Streptococcus, Thermicanus, Megasphaera spp. and Veillonella spp.). Correlation analysis indicated that body fatness and waist circumference negatively correlated with Bacteroidetes taxa, while Firmicutes taxa positively correlated with body fat and negatively with muscle mass and/or physical activity level. Furthermore, the relative abundance of several bacterial taxa belonging to Enterobacteriaceae family, known to exhibit endotoxic activity, was increased in the OB group compared to NW. The results extend our knowledge on the GM profiles in Italian OB, identifying novel taxa linking obesity and intestine.
format	article
author	Vanessa Palmas Silvia Pisanu Veronica Madau Emanuela Casula Andrea Deledda Roberto Cusano Paolo Uva Sarah Vascellari Andrea Loviselli Aldo Manzin Fernanda Velluzzi
author_facet	Vanessa Palmas Silvia Pisanu Veronica Madau Emanuela Casula Andrea Deledda Roberto Cusano Paolo Uva Sarah Vascellari Andrea Loviselli Aldo Manzin Fernanda Velluzzi
author_sort	Vanessa Palmas
title	Gut microbiota markers associated with obesity and overweight in Italian adults
title_short	Gut microbiota markers associated with obesity and overweight in Italian adults
title_full	Gut microbiota markers associated with obesity and overweight in Italian adults
title_fullStr	Gut microbiota markers associated with obesity and overweight in Italian adults
title_full_unstemmed	Gut microbiota markers associated with obesity and overweight in Italian adults
title_sort	gut microbiota markers associated with obesity and overweight in italian adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/11438df90bd04dbc9713709fbb71bc0a
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Gut microbiota markers associated with obesity and overweight in Italian adults

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