Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

Neutrophil elastase cleaves thrombin generating anti-inflammatory peptides. Here the authors show that cleavage of thrombin by Pseudomonas aeruginosaelastase generates a peptide that prevents TLR dimerization and signaling, interfering with the inflammatory response to avoid host defense.

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Autores principales:	Mariena J. A. van der Plas, Ravi K. V. Bhongir, Sven Kjellström, Helena Siller, Gopinath Kasetty, Matthias Mörgelin, Artur Schmidtchen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1143f94b90fb4bf195cbd8188246946e
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spelling	oai:doaj.org-article:1143f94b90fb4bf195cbd8188246946e2021-12-02T15:35:00ZPseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses10.1038/ncomms115672041-1723https://doaj.org/article/1143f94b90fb4bf195cbd8188246946e2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11567https://doaj.org/toc/2041-1723Neutrophil elastase cleaves thrombin generating anti-inflammatory peptides. Here the authors show that cleavage of thrombin by Pseudomonas aeruginosaelastase generates a peptide that prevents TLR dimerization and signaling, interfering with the inflammatory response to avoid host defense.Mariena J. A. van der PlasRavi K. V. BhongirSven KjellströmHelena SillerGopinath KasettyMatthias MörgelinArtur SchmidtchenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariena J. A. van der Plas Ravi K. V. Bhongir Sven Kjellström Helena Siller Gopinath Kasetty Matthias Mörgelin Artur Schmidtchen Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
description	Neutrophil elastase cleaves thrombin generating anti-inflammatory peptides. Here the authors show that cleavage of thrombin by Pseudomonas aeruginosaelastase generates a peptide that prevents TLR dimerization and signaling, interfering with the inflammatory response to avoid host defense.
format	article
author	Mariena J. A. van der Plas Ravi K. V. Bhongir Sven Kjellström Helena Siller Gopinath Kasetty Matthias Mörgelin Artur Schmidtchen
author_facet	Mariena J. A. van der Plas Ravi K. V. Bhongir Sven Kjellström Helena Siller Gopinath Kasetty Matthias Mörgelin Artur Schmidtchen
author_sort	Mariena J. A. van der Plas
title	Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_short	Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_full	Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_fullStr	Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_full_unstemmed	Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses
title_sort	pseudomonas aeruginosa elastase cleaves a c-terminal peptide from human thrombin that inhibits host inflammatory responses
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1143f94b90fb4bf195cbd8188246946e
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Pseudomonas aeruginosa elastase cleaves a C-terminal peptide from human thrombin that inhibits host inflammatory responses

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