Dentine matrix metalloproteinases as potential mediators of dentine regeneration

Matrix metalloproteinases (MMPs) have been implicated not only in the regulation of developmental processes but also in the release of biologically active molecules and in the modulation of repair during tertiary dentine formation. Although efforts to preserve dentine have focused on inhibiting the...

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Autores principales:	E Guirado, A George
Formato:	article
Lenguaje:	EN
Publicado:	AO Research Institute Davos 2021
Materias:	dentine enamel periodontal ligament tooth dental regenerative repair matrix metalloproteinases dental physiology signalling molecules/growth factors Surgery RD1-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/1149fc7d1deb4b68bb4500c3df1cf208
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id	oai:doaj.org-article:1149fc7d1deb4b68bb4500c3df1cf208
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spelling	oai:doaj.org-article:1149fc7d1deb4b68bb4500c3df1cf2082021-11-24T17:22:15ZDentine matrix metalloproteinases as potential mediators of dentine regeneration10.22203/eCM.v042a241473-2262https://doaj.org/article/1149fc7d1deb4b68bb4500c3df1cf2082021-11-01T00:00:00Zhttps://www.ecmjournal.org/papers/vol042/pdf/v042a24.pdfhttps://doaj.org/toc/1473-2262Matrix metalloproteinases (MMPs) have been implicated not only in the regulation of developmental processes but also in the release of biologically active molecules and in the modulation of repair during tertiary dentine formation. Although efforts to preserve dentine have focused on inhibiting the activity of these proteases, their function is much more complex and necessary for dentine repair than expected. The present review explores the role of MMPs as bioactive components of the dentine matrix involved in dentine formation, repair and regeneration. Special consideration is given to the mechanical properties of dentine, including those of reactionary and reparative dentine, and the known roles of MMPs in their formation. MMPs are critical components of the dentine matrix and should be considered as important candidates in dentine regeneration.E GuiradoA George AO Research Institute Davosarticledentineenamelperiodontal ligamenttoothdental regenerative repairmatrix metalloproteinasesdental physiologysignalling molecules/growth factorsSurgeryRD1-811Diseases of the musculoskeletal systemRC925-935ENEuropean Cells & Materials, Vol 42, Pp 392-400 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dentine enamel periodontal ligament tooth dental regenerative repair matrix metalloproteinases dental physiology signalling molecules/growth factors Surgery RD1-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	dentine enamel periodontal ligament tooth dental regenerative repair matrix metalloproteinases dental physiology signalling molecules/growth factors Surgery RD1-811 Diseases of the musculoskeletal system RC925-935 E Guirado A George Dentine matrix metalloproteinases as potential mediators of dentine regeneration
description	Matrix metalloproteinases (MMPs) have been implicated not only in the regulation of developmental processes but also in the release of biologically active molecules and in the modulation of repair during tertiary dentine formation. Although efforts to preserve dentine have focused on inhibiting the activity of these proteases, their function is much more complex and necessary for dentine repair than expected. The present review explores the role of MMPs as bioactive components of the dentine matrix involved in dentine formation, repair and regeneration. Special consideration is given to the mechanical properties of dentine, including those of reactionary and reparative dentine, and the known roles of MMPs in their formation. MMPs are critical components of the dentine matrix and should be considered as important candidates in dentine regeneration.
format	article
author	E Guirado A George
author_facet	E Guirado A George
author_sort	E Guirado
title	Dentine matrix metalloproteinases as potential mediators of dentine regeneration
title_short	Dentine matrix metalloproteinases as potential mediators of dentine regeneration
title_full	Dentine matrix metalloproteinases as potential mediators of dentine regeneration
title_fullStr	Dentine matrix metalloproteinases as potential mediators of dentine regeneration
title_full_unstemmed	Dentine matrix metalloproteinases as potential mediators of dentine regeneration
title_sort	dentine matrix metalloproteinases as potential mediators of dentine regeneration
publisher	AO Research Institute Davos
publishDate	2021
url	https://doaj.org/article/1149fc7d1deb4b68bb4500c3df1cf208
work_keys_str_mv	AT eguirado dentinematrixmetalloproteinasesaspotentialmediatorsofdentineregeneration AT ageorge dentinematrixmetalloproteinasesaspotentialmediatorsofdentineregeneration
_version_	1718414736321675264

Dentine matrix metalloproteinases as potential mediators of dentine regeneration

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