A circular RNA generated from an intron of the insulin gene controls insulin secretion
Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its level is reduced in the islets of diabetic subjects.
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Nature Portfolio
2020
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oai:doaj.org-article:114bb60757e446fba74489bec09b7aca2021-12-02T15:39:21ZA circular RNA generated from an intron of the insulin gene controls insulin secretion10.1038/s41467-020-19381-w2041-1723https://doaj.org/article/114bb60757e446fba74489bec09b7aca2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19381-whttps://doaj.org/toc/2041-1723Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its level is reduced in the islets of diabetic subjects.Lisa StollAdriana Rodríguez-TrejoClaudiane GuayFlora BrozziMustafa Bilal BayazitSonia GattescoVéronique MenoudJonathan SobelAna Claudia MarquesMorten Trillingsgaard VenøJonathan Lou S. EsguerraMohammad BarghouthMara SuleimanLorella MarselliJørgen KjemsLena EliassonErik RenströmKarim BouzakriMichel PingetPiero MarchettiRomano RegazziNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lisa Stoll Adriana Rodríguez-Trejo Claudiane Guay Flora Brozzi Mustafa Bilal Bayazit Sonia Gattesco Véronique Menoud Jonathan Sobel Ana Claudia Marques Morten Trillingsgaard Venø Jonathan Lou S. Esguerra Mohammad Barghouth Mara Suleiman Lorella Marselli Jørgen Kjems Lena Eliasson Erik Renström Karim Bouzakri Michel Pinget Piero Marchetti Romano Regazzi A circular RNA generated from an intron of the insulin gene controls insulin secretion |
| description |
Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its level is reduced in the islets of diabetic subjects. |
| format |
article |
| author |
Lisa Stoll Adriana Rodríguez-Trejo Claudiane Guay Flora Brozzi Mustafa Bilal Bayazit Sonia Gattesco Véronique Menoud Jonathan Sobel Ana Claudia Marques Morten Trillingsgaard Venø Jonathan Lou S. Esguerra Mohammad Barghouth Mara Suleiman Lorella Marselli Jørgen Kjems Lena Eliasson Erik Renström Karim Bouzakri Michel Pinget Piero Marchetti Romano Regazzi |
| author_facet |
Lisa Stoll Adriana Rodríguez-Trejo Claudiane Guay Flora Brozzi Mustafa Bilal Bayazit Sonia Gattesco Véronique Menoud Jonathan Sobel Ana Claudia Marques Morten Trillingsgaard Venø Jonathan Lou S. Esguerra Mohammad Barghouth Mara Suleiman Lorella Marselli Jørgen Kjems Lena Eliasson Erik Renström Karim Bouzakri Michel Pinget Piero Marchetti Romano Regazzi |
| author_sort |
Lisa Stoll |
| title |
A circular RNA generated from an intron of the insulin gene controls insulin secretion |
| title_short |
A circular RNA generated from an intron of the insulin gene controls insulin secretion |
| title_full |
A circular RNA generated from an intron of the insulin gene controls insulin secretion |
| title_fullStr |
A circular RNA generated from an intron of the insulin gene controls insulin secretion |
| title_full_unstemmed |
A circular RNA generated from an intron of the insulin gene controls insulin secretion |
| title_sort |
circular rna generated from an intron of the insulin gene controls insulin secretion |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/114bb60757e446fba74489bec09b7aca |
| work_keys_str_mv |
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