Physical basis for the determination of lumen shape in a simple epithelium

The formation of a hollow lumen surrounded by cells is a key developmental process that sets the shape of tissues and organs. Here, the authors show how the combined influence of geometric constraints imposed by cell packing and osmotic pressure can generate the diverse range in lumen shapes observe...

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Autores principales: Claudia G. Vasquez, Vipul T. Vachharajani, Carlos Garzon-Coral, Alexander R. Dunn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/114c674fd5ef4820af612699a1723983
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Sumario:The formation of a hollow lumen surrounded by cells is a key developmental process that sets the shape of tissues and organs. Here, the authors show how the combined influence of geometric constraints imposed by cell packing and osmotic pressure can generate the diverse range in lumen shapes observed in different tissues.