Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production

Evolution: Toughening up biofilms in lungs Bacteria in lungs of people with cystic fibrosis can evolve through decades to build a tough biofilm that resists the body’s defences. Vernita Gordon and colleagues at the University of Texas, with co-workers in Europe, examined biofilms cultured from lung...

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Autores principales:	Kristin Kovach, Megan Davis-Fields, Yasuhiko Irie, Kanishk Jain, Shashvat Doorwar, Katherine Vuong, Numa Dhamani, Kishore Mohanty, Ahmed Touhami, Vernita D Gordon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/114d584f35b8491a97c9e4fd5cfa9a74
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spelling	oai:doaj.org-article:114d584f35b8491a97c9e4fd5cfa9a742021-12-02T11:42:16ZEvolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production10.1038/s41522-016-0007-92055-5008https://doaj.org/article/114d584f35b8491a97c9e4fd5cfa9a742017-01-01T00:00:00Zhttps://doi.org/10.1038/s41522-016-0007-9https://doaj.org/toc/2055-5008Evolution: Toughening up biofilms in lungs Bacteria in lungs of people with cystic fibrosis can evolve through decades to build a tough biofilm that resists the body’s defences. Vernita Gordon and colleagues at the University of Texas, with co-workers in Europe, examined biofilms cultured from lung samples taken from patients at intervals over many years. The infecting bacterial populations had steadily evolved to increase production of specific carbohydrate components of the biofilms. The researchers found that increasing production of one carbohydrate component strengthens the biofilms, most likely due to the carbohydrate being crosslinked by protein molecules. The investigation suggests that the mechanics of the carbohydrate-protein network protects the biofilms from being broken into smaller pieces that can be engulfed by defensive cells called phagocytes. This new insight into the evolution of mechanical toughness complements the previously observed evolution of increasing chemical protection. Understanding these processes will assist efforts to combat them.Kristin KovachMegan Davis-FieldsYasuhiko IrieKanishk JainShashvat DoorwarKatherine VuongNuma DhamaniKishore MohantyAhmed TouhamiVernita D GordonNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 3, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Kristin Kovach Megan Davis-Fields Yasuhiko Irie Kanishk Jain Shashvat Doorwar Katherine Vuong Numa Dhamani Kishore Mohanty Ahmed Touhami Vernita D Gordon Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production
description	Evolution: Toughening up biofilms in lungs Bacteria in lungs of people with cystic fibrosis can evolve through decades to build a tough biofilm that resists the body’s defences. Vernita Gordon and colleagues at the University of Texas, with co-workers in Europe, examined biofilms cultured from lung samples taken from patients at intervals over many years. The infecting bacterial populations had steadily evolved to increase production of specific carbohydrate components of the biofilms. The researchers found that increasing production of one carbohydrate component strengthens the biofilms, most likely due to the carbohydrate being crosslinked by protein molecules. The investigation suggests that the mechanics of the carbohydrate-protein network protects the biofilms from being broken into smaller pieces that can be engulfed by defensive cells called phagocytes. This new insight into the evolution of mechanical toughness complements the previously observed evolution of increasing chemical protection. Understanding these processes will assist efforts to combat them.
format	article
author	Kristin Kovach Megan Davis-Fields Yasuhiko Irie Kanishk Jain Shashvat Doorwar Katherine Vuong Numa Dhamani Kishore Mohanty Ahmed Touhami Vernita D Gordon
author_facet	Kristin Kovach Megan Davis-Fields Yasuhiko Irie Kanishk Jain Shashvat Doorwar Katherine Vuong Numa Dhamani Kishore Mohanty Ahmed Touhami Vernita D Gordon
author_sort	Kristin Kovach
title	Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production
title_short	Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production
title_full	Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production
title_fullStr	Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production
title_full_unstemmed	Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production
title_sort	evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/114d584f35b8491a97c9e4fd5cfa9a74
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Evolutionary adaptations of biofilms infecting cystic fibrosis lungs promote mechanical toughness by adjusting polysaccharide production

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