Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments

Tools to investigate a wide range of 3D microenvironmental parameters are important for understanding and controlling cell fate. Here, the authors develop hydrogels with orthogonal biochemical gradients and use this screening system to identify microenvironments that induce mesenchymal stem cell cho...

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Autores principales: Sebastián L. Vega, Mi Y. Kwon, Kwang Hoon Song, Chao Wang, Robert L. Mauck, Lin Han, Jason A. Burdick
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/11507bb8c73040a1865c58bbe5cb6744
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Sumario:Tools to investigate a wide range of 3D microenvironmental parameters are important for understanding and controlling cell fate. Here, the authors develop hydrogels with orthogonal biochemical gradients and use this screening system to identify microenvironments that induce mesenchymal stem cell chondrogenesis.