Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma

Abstract We examined the prognostic significance of Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3) expression and its correlations with mesenchymal phenotype and microvessel density in non-small cell lung carcinoma (NSCLC). A total of 268 NSCLC specimens were evaluated r...

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Autores principales:	Dongjun Jeong, Seona Ban, Seunghyun Oh, Su Jin Lee, Seong Yong Park, Young Wha Koh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1151263f809e4b1d9d7435f6fe1eb8ec
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spelling	oai:doaj.org-article:1151263f809e4b1d9d7435f6fe1eb8ec2021-12-02T11:53:06ZPrognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma10.1038/s41598-017-08851-92045-2322https://doaj.org/article/1151263f809e4b1d9d7435f6fe1eb8ec2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08851-9https://doaj.org/toc/2045-2322Abstract We examined the prognostic significance of Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3) expression and its correlations with mesenchymal phenotype and microvessel density in non-small cell lung carcinoma (NSCLC). A total of 268 NSCLC specimens were evaluated retrospectively by immunohistochemical staining for EDIL3, EMT markers (e-cadherin, β-catenin, and vimentin), and CD31 to measure microvessel density. EDIL3, e-cadherin, β-catenin, and vimentin were expressed in 16%, 22.8%, 3.7%, and 10.1% of the specimens, respectively. The mRNA level of EDIL3 in tumor was correlated with the level of EDIL3 protein expression using immunohistochemistry. In lung adenocarcinoma patients, EDIL3 expression was significantly correlated with low e-cadherin expression, high vimentin expression, and increased microvessel density (P < 0.001, P = 0.001, and P = 0.023, respectively). In lung squamous cell carcinoma patients, EDIL3 expression was significantly correlated with low e-cadherin expression and high vimentin expression (P = 0.021 and P = 0.002, respectively). In lung adenocarcinoma patients, EDIL3 was an independent prognostic factor for overall survival in a multivariate analysis (hazard ratio: 2.552, P = 0.004). EDIL3 is significantly correlated with mesenchymal phenotype, angiogenesis, and tumor progression in lung adenocarcinoma.Dongjun JeongSeona BanSeunghyun OhSu Jin LeeSeong Yong ParkYoung Wha KohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dongjun Jeong Seona Ban Seunghyun Oh Su Jin Lee Seong Yong Park Young Wha Koh Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma
description	Abstract We examined the prognostic significance of Epidermal Growth Factor-like repeats and Discoidin I-Like Domains 3 (EDIL3) expression and its correlations with mesenchymal phenotype and microvessel density in non-small cell lung carcinoma (NSCLC). A total of 268 NSCLC specimens were evaluated retrospectively by immunohistochemical staining for EDIL3, EMT markers (e-cadherin, β-catenin, and vimentin), and CD31 to measure microvessel density. EDIL3, e-cadherin, β-catenin, and vimentin were expressed in 16%, 22.8%, 3.7%, and 10.1% of the specimens, respectively. The mRNA level of EDIL3 in tumor was correlated with the level of EDIL3 protein expression using immunohistochemistry. In lung adenocarcinoma patients, EDIL3 expression was significantly correlated with low e-cadherin expression, high vimentin expression, and increased microvessel density (P < 0.001, P = 0.001, and P = 0.023, respectively). In lung squamous cell carcinoma patients, EDIL3 expression was significantly correlated with low e-cadherin expression and high vimentin expression (P = 0.021 and P = 0.002, respectively). In lung adenocarcinoma patients, EDIL3 was an independent prognostic factor for overall survival in a multivariate analysis (hazard ratio: 2.552, P = 0.004). EDIL3 is significantly correlated with mesenchymal phenotype, angiogenesis, and tumor progression in lung adenocarcinoma.
format	article
author	Dongjun Jeong Seona Ban Seunghyun Oh Su Jin Lee Seong Yong Park Young Wha Koh
author_facet	Dongjun Jeong Seona Ban Seunghyun Oh Su Jin Lee Seong Yong Park Young Wha Koh
author_sort	Dongjun Jeong
title	Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma
title_short	Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma
title_full	Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma
title_fullStr	Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma
title_full_unstemmed	Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma
title_sort	prognostic significance of edil3 expression and correlation with mesenchymal phenotype and microvessel density in lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1151263f809e4b1d9d7435f6fe1eb8ec
work_keys_str_mv	AT dongjunjeong prognosticsignificanceofedil3expressionandcorrelationwithmesenchymalphenotypeandmicrovesseldensityinlungadenocarcinoma AT seonaban prognosticsignificanceofedil3expressionandcorrelationwithmesenchymalphenotypeandmicrovesseldensityinlungadenocarcinoma AT seunghyunoh prognosticsignificanceofedil3expressionandcorrelationwithmesenchymalphenotypeandmicrovesseldensityinlungadenocarcinoma AT sujinlee prognosticsignificanceofedil3expressionandcorrelationwithmesenchymalphenotypeandmicrovesseldensityinlungadenocarcinoma AT seongyongpark prognosticsignificanceofedil3expressionandcorrelationwithmesenchymalphenotypeandmicrovesseldensityinlungadenocarcinoma AT youngwhakoh prognosticsignificanceofedil3expressionandcorrelationwithmesenchymalphenotypeandmicrovesseldensityinlungadenocarcinoma
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Prognostic Significance of EDIL3 Expression and Correlation with Mesenchymal Phenotype and Microvessel Density in Lung Adenocarcinoma

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