Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy
Wei Zheng,1 Miao-Ling Jiang,1 Hong-Bo He,1 Ri-Peng Li,1 Qi-Long Li,1 Chun-Ping Zhang,1 Su-Miao Zhou,1 Su Yan,1 Yu-Ping Ning,1,2 Xiong Huang1 1The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, People’s Republic of China; 2The First School o...
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Dove Medical Press
2020
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oai:doaj.org-article:11518a27d27f44e791615ad7536b9d1d2021-12-02T08:30:44ZSerum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy1178-2021https://doaj.org/article/11518a27d27f44e791615ad7536b9d1d2020-06-01T00:00:00Zhttps://www.dovepress.com/serum-bdnf-levels-are-not-associated-with-the-antidepressant-effects-o-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Wei Zheng,1 Miao-Ling Jiang,1 Hong-Bo He,1 Ri-Peng Li,1 Qi-Long Li,1 Chun-Ping Zhang,1 Su-Miao Zhou,1 Su Yan,1 Yu-Ping Ning,1,2 Xiong Huang1 1The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, People’s Republic of China; 2The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Xiong Huang; Yu-Ping NingThe Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), 36 Mingxin Road, Liwan District, Guangzhou, People’s Republic of ChinaTel +86-189-22165303; +86-185-10808443Fax +86-20-81778484; +86-20-81891425Email 1195768576@qq.com; ningjeny@126.comObjective: Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression and in the antidepressant response. This study examined whether changes in serum BDNF levels are associated with the antidepressant effects of nonconvulsive electrotherapy (NET).Methods: For BDNF analyses, serum samples were collected from 20 patients with treatment-refractory depression (TRD) and from 20 healthy controls. Serum samples were also collected from patients following a course of NET.Results: Although significantly lower baseline serum BDNF levels were observed in TRD patients than in healthy controls, no changes in serum BDNF levels were found in TRD patients after a course of NET compared to baseline. No significant association was found between serum BDNF levels and depression severity.Conclusion: Serum BDNF levels appear to have no clinical utility in the prediction of the antidepressant effects of NET in patients with TRD. Future studies of higher quality and with larger sample sizes are needed to confirm these findings.Keywords: brain-derived neurotrophic factor, nonconvulsive electrotherapy, treatment-refractory depressionZheng WJiang MLHe HBLi RPLi QLZhang CPZhou SMYan SNing YPHuang XDove Medical Pressarticlebrain-derived neurotrophic factornonconvulsive electrotherapytreatment-refractory depressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1555-1560 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
brain-derived neurotrophic factor nonconvulsive electrotherapy treatment-refractory depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
brain-derived neurotrophic factor nonconvulsive electrotherapy treatment-refractory depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zheng W Jiang ML He HB Li RP Li QL Zhang CP Zhou SM Yan S Ning YP Huang X Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy |
| description |
Wei Zheng,1 Miao-Ling Jiang,1 Hong-Bo He,1 Ri-Peng Li,1 Qi-Long Li,1 Chun-Ping Zhang,1 Su-Miao Zhou,1 Su Yan,1 Yu-Ping Ning,1,2 Xiong Huang1 1The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, People’s Republic of China; 2The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Xiong Huang; Yu-Ping NingThe Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), 36 Mingxin Road, Liwan District, Guangzhou, People’s Republic of ChinaTel +86-189-22165303; +86-185-10808443Fax +86-20-81778484; +86-20-81891425Email 1195768576@qq.com; ningjeny@126.comObjective: Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of depression and in the antidepressant response. This study examined whether changes in serum BDNF levels are associated with the antidepressant effects of nonconvulsive electrotherapy (NET).Methods: For BDNF analyses, serum samples were collected from 20 patients with treatment-refractory depression (TRD) and from 20 healthy controls. Serum samples were also collected from patients following a course of NET.Results: Although significantly lower baseline serum BDNF levels were observed in TRD patients than in healthy controls, no changes in serum BDNF levels were found in TRD patients after a course of NET compared to baseline. No significant association was found between serum BDNF levels and depression severity.Conclusion: Serum BDNF levels appear to have no clinical utility in the prediction of the antidepressant effects of NET in patients with TRD. Future studies of higher quality and with larger sample sizes are needed to confirm these findings.Keywords: brain-derived neurotrophic factor, nonconvulsive electrotherapy, treatment-refractory depression |
| format |
article |
| author |
Zheng W Jiang ML He HB Li RP Li QL Zhang CP Zhou SM Yan S Ning YP Huang X |
| author_facet |
Zheng W Jiang ML He HB Li RP Li QL Zhang CP Zhou SM Yan S Ning YP Huang X |
| author_sort |
Zheng W |
| title |
Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy |
| title_short |
Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy |
| title_full |
Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy |
| title_fullStr |
Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy |
| title_full_unstemmed |
Serum BDNF Levels are Not Associated with the Antidepressant Effects of Nonconvulsive Electrotherapy |
| title_sort |
serum bdnf levels are not associated with the antidepressant effects of nonconvulsive electrotherapy |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/11518a27d27f44e791615ad7536b9d1d |
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