A Web Tool for Consensus Gene Regulatory Network Construction

Gene regulatory network (GRN) construction involves various steps of complex computational steps. This step-by-step procedure requires prior knowledge of programming languages such as R. Development of a web tool may reduce this complexity in the analysis steps which can be easy accessible for the u...

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Autores principales:	Chiranjib Sarkar, Rajender Parsad, Dwijesh C. Mishra, Anil Rai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	web tool PHP fisher’s weighted method consensus approach gene regulatory network Genetics QH426-470
Acceso en línea:	https://doaj.org/article/1153465da3a94f7b89f7b714f6ddf53e
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id	oai:doaj.org-article:1153465da3a94f7b89f7b714f6ddf53e
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spelling	oai:doaj.org-article:1153465da3a94f7b89f7b714f6ddf53e2021-11-30T18:28:15ZA Web Tool for Consensus Gene Regulatory Network Construction1664-802110.3389/fgene.2021.745827https://doaj.org/article/1153465da3a94f7b89f7b714f6ddf53e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.745827/fullhttps://doaj.org/toc/1664-8021Gene regulatory network (GRN) construction involves various steps of complex computational steps. This step-by-step procedure requires prior knowledge of programming languages such as R. Development of a web tool may reduce this complexity in the analysis steps which can be easy accessible for the user. In this study, a web tool for constructing consensus GRN by combining the outcomes obtained from four methods, namely, correlation, principal component regression, partial least square, and ridge regression, has been developed. We have designed the web tool with an interactive and user-friendly web page using the php programming language. We have used R script for the analysis steps which run in the background of the user interface. Users can upload gene expression data for constructing consensus GRN. The output obtained from analysis will be available in downloadable form in the result window of the web tool.Chiranjib SarkarRajender ParsadDwijesh C. MishraAnil RaiFrontiers Media S.A.articleweb toolPHPfisher’s weighted methodconsensus approachgene regulatory networkGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	web tool PHP fisher’s weighted method consensus approach gene regulatory network Genetics QH426-470
spellingShingle	web tool PHP fisher’s weighted method consensus approach gene regulatory network Genetics QH426-470 Chiranjib Sarkar Rajender Parsad Dwijesh C. Mishra Anil Rai A Web Tool for Consensus Gene Regulatory Network Construction
description	Gene regulatory network (GRN) construction involves various steps of complex computational steps. This step-by-step procedure requires prior knowledge of programming languages such as R. Development of a web tool may reduce this complexity in the analysis steps which can be easy accessible for the user. In this study, a web tool for constructing consensus GRN by combining the outcomes obtained from four methods, namely, correlation, principal component regression, partial least square, and ridge regression, has been developed. We have designed the web tool with an interactive and user-friendly web page using the php programming language. We have used R script for the analysis steps which run in the background of the user interface. Users can upload gene expression data for constructing consensus GRN. The output obtained from analysis will be available in downloadable form in the result window of the web tool.
format	article
author	Chiranjib Sarkar Rajender Parsad Dwijesh C. Mishra Anil Rai
author_facet	Chiranjib Sarkar Rajender Parsad Dwijesh C. Mishra Anil Rai
author_sort	Chiranjib Sarkar
title	A Web Tool for Consensus Gene Regulatory Network Construction
title_short	A Web Tool for Consensus Gene Regulatory Network Construction
title_full	A Web Tool for Consensus Gene Regulatory Network Construction
title_fullStr	A Web Tool for Consensus Gene Regulatory Network Construction
title_full_unstemmed	A Web Tool for Consensus Gene Regulatory Network Construction
title_sort	web tool for consensus gene regulatory network construction
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1153465da3a94f7b89f7b714f6ddf53e
work_keys_str_mv	AT chiranjibsarkar awebtoolforconsensusgeneregulatorynetworkconstruction AT rajenderparsad awebtoolforconsensusgeneregulatorynetworkconstruction AT dwijeshcmishra awebtoolforconsensusgeneregulatorynetworkconstruction AT anilrai awebtoolforconsensusgeneregulatorynetworkconstruction AT chiranjibsarkar webtoolforconsensusgeneregulatorynetworkconstruction AT rajenderparsad webtoolforconsensusgeneregulatorynetworkconstruction AT dwijeshcmishra webtoolforconsensusgeneregulatorynetworkconstruction AT anilrai webtoolforconsensusgeneregulatorynetworkconstruction
_version_	1718406363738013696

A Web Tool for Consensus Gene Regulatory Network Construction

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