Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes

Leishmania donovani is a protozoan parasite that can cause fatal infections in humans. Here the authors present a high resolution cryoEM structure of the L. donovani80S ribosome and compare it to its human counterpart to provide insight into the basis for drug selectivity towards this eukaryotic par...

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Autores principales:	Xing Zhang, Mason Lai, Winston Chang, Iris Yu, Ke Ding, Jan Mrazek, Hwee L. Ng, Otto O. Yang, Dmitri A. Maslov, Z. Hong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1154743d0e8144f0856a3f08e5888496
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spelling	oai:doaj.org-article:1154743d0e8144f0856a3f08e58884962021-12-02T16:58:23ZStructures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes10.1038/ncomms132232041-1723https://doaj.org/article/1154743d0e8144f0856a3f08e58884962016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13223https://doaj.org/toc/2041-1723Leishmania donovani is a protozoan parasite that can cause fatal infections in humans. Here the authors present a high resolution cryoEM structure of the L. donovani80S ribosome and compare it to its human counterpart to provide insight into the basis for drug selectivity towards this eukaryotic parasite.Xing ZhangMason LaiWinston ChangIris YuKe DingJan MrazekHwee L. NgOtto O. YangDmitri A. MaslovZ. Hong ZhouNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xing Zhang Mason Lai Winston Chang Iris Yu Ke Ding Jan Mrazek Hwee L. Ng Otto O. Yang Dmitri A. Maslov Z. Hong Zhou Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes
description	Leishmania donovani is a protozoan parasite that can cause fatal infections in humans. Here the authors present a high resolution cryoEM structure of the L. donovani80S ribosome and compare it to its human counterpart to provide insight into the basis for drug selectivity towards this eukaryotic parasite.
format	article
author	Xing Zhang Mason Lai Winston Chang Iris Yu Ke Ding Jan Mrazek Hwee L. Ng Otto O. Yang Dmitri A. Maslov Z. Hong Zhou
author_facet	Xing Zhang Mason Lai Winston Chang Iris Yu Ke Ding Jan Mrazek Hwee L. Ng Otto O. Yang Dmitri A. Maslov Z. Hong Zhou
author_sort	Xing Zhang
title	Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes
title_short	Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes
title_full	Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes
title_fullStr	Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes
title_full_unstemmed	Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes
title_sort	structures and stabilization of kinetoplastid-specific split rrnas revealed by comparing leishmanial and human ribosomes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1154743d0e8144f0856a3f08e5888496
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Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes

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