Increased global transcription activity as a mechanism of replication stress in cancer

Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage.

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Autores principales:	Panagiotis Kotsantis, Lara Marques Silva, Sarah Irmscher, Rebecca M. Jones, Lisa Folkes, Natalia Gromak, Eva Petermann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11549dd2c7d8445a96d11f1f28cfaa77
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spelling	oai:doaj.org-article:11549dd2c7d8445a96d11f1f28cfaa772021-12-02T16:49:58ZIncreased global transcription activity as a mechanism of replication stress in cancer10.1038/ncomms130872041-1723https://doaj.org/article/11549dd2c7d8445a96d11f1f28cfaa772016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13087https://doaj.org/toc/2041-1723Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage.Panagiotis KotsantisLara Marques SilvaSarah IrmscherRebecca M. JonesLisa FolkesNatalia GromakEva PetermannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Panagiotis Kotsantis Lara Marques Silva Sarah Irmscher Rebecca M. Jones Lisa Folkes Natalia Gromak Eva Petermann Increased global transcription activity as a mechanism of replication stress in cancer
description	Cancer cells proliferate at high rates and incur replication stress. Here, the authors show that this can be the consequence of oncogene-induced higher transcriptional activity, which, through increased RNA synthesis and R-loop accumulation, results in replication fork slowing and DNA damage.
format	article
author	Panagiotis Kotsantis Lara Marques Silva Sarah Irmscher Rebecca M. Jones Lisa Folkes Natalia Gromak Eva Petermann
author_facet	Panagiotis Kotsantis Lara Marques Silva Sarah Irmscher Rebecca M. Jones Lisa Folkes Natalia Gromak Eva Petermann
author_sort	Panagiotis Kotsantis
title	Increased global transcription activity as a mechanism of replication stress in cancer
title_short	Increased global transcription activity as a mechanism of replication stress in cancer
title_full	Increased global transcription activity as a mechanism of replication stress in cancer
title_fullStr	Increased global transcription activity as a mechanism of replication stress in cancer
title_full_unstemmed	Increased global transcription activity as a mechanism of replication stress in cancer
title_sort	increased global transcription activity as a mechanism of replication stress in cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/11549dd2c7d8445a96d11f1f28cfaa77
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Increased global transcription activity as a mechanism of replication stress in cancer

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