Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “pathogenic” mouse TH 17 but distinct from “no...

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Autores principales:	Dan Hu, Samuele Notarbartolo, Tom Croonenborghs, Bonny Patel, Ron Cialic, Tun-Hsiang Yang, Dominik Aschenbrenner, Karin M. Andersson, Marco Gattorno, Minh Pham, Pia Kivisakk, Isabelle V. Pierre, Youjin Lee, Karun Kiani, Maria Bokarewa, Emily Tjon, Nathalie Pochet, Federica Sallusto, Vijay K. Kuchroo, Howard L. Weiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11569c6b2d2b489ab5a6e3fe5796dc19
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spelling	oai:doaj.org-article:11569c6b2d2b489ab5a6e3fe5796dc192021-12-02T15:38:35ZTranscriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis10.1038/s41467-017-01571-82041-1723https://doaj.org/article/11569c6b2d2b489ab5a6e3fe5796dc192017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01571-8https://doaj.org/toc/2041-1723CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “pathogenic” mouse TH 17 but distinct from “non-pathogenic” mouse TH 17.Dan HuSamuele NotarbartoloTom CroonenborghsBonny PatelRon CialicTun-Hsiang YangDominik AschenbrennerKarin M. AnderssonMarco GattornoMinh PhamPia KivisakkIsabelle V. PierreYoujin LeeKarun KianiMaria BokarewaEmily TjonNathalie PochetFederica SallustoVijay K. KuchrooHoward L. WeinerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dan Hu Samuele Notarbartolo Tom Croonenborghs Bonny Patel Ron Cialic Tun-Hsiang Yang Dominik Aschenbrenner Karin M. Andersson Marco Gattorno Minh Pham Pia Kivisakk Isabelle V. Pierre Youjin Lee Karun Kiani Maria Bokarewa Emily Tjon Nathalie Pochet Federica Sallusto Vijay K. Kuchroo Howard L. Weiner Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
description	CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “pathogenic” mouse TH 17 but distinct from “non-pathogenic” mouse TH 17.
format	article
author	Dan Hu Samuele Notarbartolo Tom Croonenborghs Bonny Patel Ron Cialic Tun-Hsiang Yang Dominik Aschenbrenner Karin M. Andersson Marco Gattorno Minh Pham Pia Kivisakk Isabelle V. Pierre Youjin Lee Karun Kiani Maria Bokarewa Emily Tjon Nathalie Pochet Federica Sallusto Vijay K. Kuchroo Howard L. Weiner
author_facet	Dan Hu Samuele Notarbartolo Tom Croonenborghs Bonny Patel Ron Cialic Tun-Hsiang Yang Dominik Aschenbrenner Karin M. Andersson Marco Gattorno Minh Pham Pia Kivisakk Isabelle V. Pierre Youjin Lee Karun Kiani Maria Bokarewa Emily Tjon Nathalie Pochet Federica Sallusto Vijay K. Kuchroo Howard L. Weiner
author_sort	Dan Hu
title	Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
title_short	Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
title_full	Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
title_fullStr	Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
title_full_unstemmed	Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis
title_sort	transcriptional signature of human pro-inflammatory th17 cells identifies reduced il10 gene expression in multiple sclerosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/11569c6b2d2b489ab5a6e3fe5796dc19
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Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

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