Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants

Abstract Epstein-Barr virus (EBV) infects greater than 90% of humans, is recognized as a significant comorbidity with HIV/AIDS, and is an etiologic agent for some human cancers. The critically endangered mountain gorilla population was suspected of infection with an EBV-like virus based on serology...

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Autores principales:	Tierra Smiley Evans, Linda J. Lowenstine, Kirsten V. Gilardi, Peter A. Barry, Benard J. Ssebide, Jean Felix Kinani, Fred Nizeyimana, Jean Bosco Noheri, Michael R. Cranfield, Antoine Mudakikwa, Tracey Goldstein, Jonna A. K. Mazet, Christine Kreuder Johnson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/115a8af1cbd34684976338917d009654
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spelling	oai:doaj.org-article:115a8af1cbd34684976338917d0096542021-12-02T15:06:18ZMountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants10.1038/s41598-017-04877-12045-2322https://doaj.org/article/115a8af1cbd34684976338917d0096542017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04877-1https://doaj.org/toc/2045-2322Abstract Epstein-Barr virus (EBV) infects greater than 90% of humans, is recognized as a significant comorbidity with HIV/AIDS, and is an etiologic agent for some human cancers. The critically endangered mountain gorilla population was suspected of infection with an EBV-like virus based on serology and infant histopathology similar to pulmonary reactive lymphoid hyperplasia (PRLH), a condition associated with EBV in HIV-infected children. To further examine the presence of EBV or an EBV-like virus in mountain gorillas, we conducted the first population-wide survey of oral samples for an EBV-like virus in a nonhuman great ape. We discovered that mountain gorillas are widely infected (n = 143/332) with a specific strain of lymphocryptovirus 1 (GbbLCV-1). Fifty-two percent of infant mountain gorillas were orally shedding GbbLCV-1, suggesting primary infection during this stage of life, similar to what is seen in humans in less developed countries. We then identified GbbLCV-1 in post-mortem infant lung tissues demonstrating histopathological lesions consistent with PRLH, suggesting primary infection with GbbLCV-1 is associated with PRLH in infants. Together, our findings demonstrate that mountain gorilla’s infection with GbbLCV-1 could provide valuable information for human disease in a natural great ape setting and have potential conservation implications in this critically endangered species.Tierra Smiley EvansLinda J. LowenstineKirsten V. GilardiPeter A. BarryBenard J. SsebideJean Felix KinaniFred NizeyimanaJean Bosco NoheriMichael R. CranfieldAntoine MudakikwaTracey GoldsteinJonna A. K. MazetChristine Kreuder JohnsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tierra Smiley Evans Linda J. Lowenstine Kirsten V. Gilardi Peter A. Barry Benard J. Ssebide Jean Felix Kinani Fred Nizeyimana Jean Bosco Noheri Michael R. Cranfield Antoine Mudakikwa Tracey Goldstein Jonna A. K. Mazet Christine Kreuder Johnson Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants
description	Abstract Epstein-Barr virus (EBV) infects greater than 90% of humans, is recognized as a significant comorbidity with HIV/AIDS, and is an etiologic agent for some human cancers. The critically endangered mountain gorilla population was suspected of infection with an EBV-like virus based on serology and infant histopathology similar to pulmonary reactive lymphoid hyperplasia (PRLH), a condition associated with EBV in HIV-infected children. To further examine the presence of EBV or an EBV-like virus in mountain gorillas, we conducted the first population-wide survey of oral samples for an EBV-like virus in a nonhuman great ape. We discovered that mountain gorillas are widely infected (n = 143/332) with a specific strain of lymphocryptovirus 1 (GbbLCV-1). Fifty-two percent of infant mountain gorillas were orally shedding GbbLCV-1, suggesting primary infection during this stage of life, similar to what is seen in humans in less developed countries. We then identified GbbLCV-1 in post-mortem infant lung tissues demonstrating histopathological lesions consistent with PRLH, suggesting primary infection with GbbLCV-1 is associated with PRLH in infants. Together, our findings demonstrate that mountain gorilla’s infection with GbbLCV-1 could provide valuable information for human disease in a natural great ape setting and have potential conservation implications in this critically endangered species.
format	article
author	Tierra Smiley Evans Linda J. Lowenstine Kirsten V. Gilardi Peter A. Barry Benard J. Ssebide Jean Felix Kinani Fred Nizeyimana Jean Bosco Noheri Michael R. Cranfield Antoine Mudakikwa Tracey Goldstein Jonna A. K. Mazet Christine Kreuder Johnson
author_facet	Tierra Smiley Evans Linda J. Lowenstine Kirsten V. Gilardi Peter A. Barry Benard J. Ssebide Jean Felix Kinani Fred Nizeyimana Jean Bosco Noheri Michael R. Cranfield Antoine Mudakikwa Tracey Goldstein Jonna A. K. Mazet Christine Kreuder Johnson
author_sort	Tierra Smiley Evans
title	Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants
title_short	Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants
title_full	Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants
title_fullStr	Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants
title_full_unstemmed	Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants
title_sort	mountain gorilla lymphocryptovirus has epstein-barr virus-like epidemiology and pathology in infants
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/115a8af1cbd34684976338917d009654
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Mountain gorilla lymphocryptovirus has Epstein-Barr virus-like epidemiology and pathology in infants

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