Effects of far infrared light on Alzheimer's disease-transgenic mice.

Far infrared light has been used in many medical procedures. However, the detailed biological mechanisms of infrared light's effects have not yet been elucidated. Many researchers have pointed out the thermal effects of treatments such as infrared saunas, which are known to increase blood flow....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Koji Fukui, Shunsuke Kimura, Yugo Kato, Masahiro Kohno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/115c1e397e214700a91e7e51054f95ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:115c1e397e214700a91e7e51054f95ba
record_format	dspace
spelling	oai:doaj.org-article:115c1e397e214700a91e7e51054f95ba2021-12-02T20:10:26ZEffects of far infrared light on Alzheimer's disease-transgenic mice.1932-620310.1371/journal.pone.0253320https://doaj.org/article/115c1e397e214700a91e7e51054f95ba2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253320https://doaj.org/toc/1932-6203Far infrared light has been used in many medical procedures. However, the detailed biological mechanisms of infrared light's effects have not yet been elucidated. Many researchers have pointed out the thermal effects of treatments such as infrared saunas, which are known to increase blood flow. Alzheimer's disease (AD) is associated with gradual decreases in brain blood flow and resulting dementia. In this study, we attempted to clarify the beneficial effects of far infrared light using the 5xFAD mouse, a transgenic model of AD. We exposed 5xFAD mice to far infrared light for 5 months. Among the far infrared-exposed AD mice, body weights were significantly decreased, and the levels of nerve growth factor and brain-derived neurotrophic factor protein were significantly increased in selected brain areas (compared to those in non-irradiated AD mice). However, cognition and motor function (as assessed by Morris water maze and Rota Rod tests, respectively) did not differ significantly between the irradiated and non-irradiated AD mouse groups. These results indicated that exposure to far infrared light may have beneficial biological effects in AD mice. However, the experimental schedule and methods may need to be modified to obtain clearer results.Koji FukuiShunsuke KimuraYugo KatoMasahiro KohnoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253320 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koji Fukui Shunsuke Kimura Yugo Kato Masahiro Kohno Effects of far infrared light on Alzheimer's disease-transgenic mice.
description	Far infrared light has been used in many medical procedures. However, the detailed biological mechanisms of infrared light's effects have not yet been elucidated. Many researchers have pointed out the thermal effects of treatments such as infrared saunas, which are known to increase blood flow. Alzheimer's disease (AD) is associated with gradual decreases in brain blood flow and resulting dementia. In this study, we attempted to clarify the beneficial effects of far infrared light using the 5xFAD mouse, a transgenic model of AD. We exposed 5xFAD mice to far infrared light for 5 months. Among the far infrared-exposed AD mice, body weights were significantly decreased, and the levels of nerve growth factor and brain-derived neurotrophic factor protein were significantly increased in selected brain areas (compared to those in non-irradiated AD mice). However, cognition and motor function (as assessed by Morris water maze and Rota Rod tests, respectively) did not differ significantly between the irradiated and non-irradiated AD mouse groups. These results indicated that exposure to far infrared light may have beneficial biological effects in AD mice. However, the experimental schedule and methods may need to be modified to obtain clearer results.
format	article
author	Koji Fukui Shunsuke Kimura Yugo Kato Masahiro Kohno
author_facet	Koji Fukui Shunsuke Kimura Yugo Kato Masahiro Kohno
author_sort	Koji Fukui
title	Effects of far infrared light on Alzheimer's disease-transgenic mice.
title_short	Effects of far infrared light on Alzheimer's disease-transgenic mice.
title_full	Effects of far infrared light on Alzheimer's disease-transgenic mice.
title_fullStr	Effects of far infrared light on Alzheimer's disease-transgenic mice.
title_full_unstemmed	Effects of far infrared light on Alzheimer's disease-transgenic mice.
title_sort	effects of far infrared light on alzheimer's disease-transgenic mice.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/115c1e397e214700a91e7e51054f95ba
work_keys_str_mv	AT kojifukui effectsoffarinfraredlightonalzheimersdiseasetransgenicmice AT shunsukekimura effectsoffarinfraredlightonalzheimersdiseasetransgenicmice AT yugokato effectsoffarinfraredlightonalzheimersdiseasetransgenicmice AT masahirokohno effectsoffarinfraredlightonalzheimersdiseasetransgenicmice
_version_	1718374984700657664

Effects of far infrared light on Alzheimer's disease-transgenic mice.

Ejemplares similares