UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possi...

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Autores principales:	Xiaoxi Li, Yanli Zhang, Liting Zheng, Mingxian Liu, Charlie Degui Chen, Hai Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/115f883b4a904c84bf10f1d3aaa7d72c
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spelling	oai:doaj.org-article:115f883b4a904c84bf10f1d3aaa7d72c2021-12-02T15:34:27ZUTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma10.1038/s41467-018-05084-w2041-1723https://doaj.org/article/115f883b4a904c84bf10f1d3aaa7d72c2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05084-whttps://doaj.org/toc/2041-1723UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possibly aggressiveness of male cancers that harbour UTX mutations.Xiaoxi LiYanli ZhangLiting ZhengMingxian LiuCharlie Degui ChenHai JiangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoxi Li Yanli Zhang Liting Zheng Mingxian Liu Charlie Degui Chen Hai Jiang UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
description	UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possibly aggressiveness of male cancers that harbour UTX mutations.
format	article
author	Xiaoxi Li Yanli Zhang Liting Zheng Mingxian Liu Charlie Degui Chen Hai Jiang
author_facet	Xiaoxi Li Yanli Zhang Liting Zheng Mingxian Liu Charlie Degui Chen Hai Jiang
author_sort	Xiaoxi Li
title	UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
title_short	UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
title_full	UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
title_fullStr	UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
title_full_unstemmed	UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
title_sort	utx is an escape from x-inactivation tumor-suppressor in b cell lymphoma
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/115f883b4a904c84bf10f1d3aaa7d72c
work_keys_str_mv	AT xiaoxili utxisanescapefromxinactivationtumorsuppressorinbcelllymphoma AT yanlizhang utxisanescapefromxinactivationtumorsuppressorinbcelllymphoma AT litingzheng utxisanescapefromxinactivationtumorsuppressorinbcelllymphoma AT mingxianliu utxisanescapefromxinactivationtumorsuppressorinbcelllymphoma AT charliedeguichen utxisanescapefromxinactivationtumorsuppressorinbcelllymphoma AT haijiang utxisanescapefromxinactivationtumorsuppressorinbcelllymphoma
_version_	1718386823647985664

UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma

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