UTX is an escape from X-inactivation tumor-suppressor in B cell lymphoma
UTX is a tumor suppressor gene located on the X-chromosome so it could potentially contribute to the cancer gender bias. Here the authors, using a mouse model of B cell lymphoma, show that UTX is a dosage sensitive tumor suppressor and may be responsible for some of the increased incidence and possi...
Guardado en:
Autores principales: | Xiaoxi Li, Yanli Zhang, Liting Zheng, Mingxian Liu, Charlie Degui Chen, Hai Jiang |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/115f883b4a904c84bf10f1d3aaa7d72c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
por: James R. Birtley, et al.
Publicado: (2019) -
Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
por: John E. Froberg, et al.
Publicado: (2018) -
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation
por: René Luijk, et al.
Publicado: (2018) -
Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphoma
por: Kristin Stirm, et al.
Publicado: (2021) -
Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
por: Seung-Beom Hong, et al.
Publicado: (2010)