How does hormesis impact biology, toxicology, and medicine?

Abstract Hormesis refers to adaptive responses of biological systems to moderate environmental or self-imposed challenges through which the system improves its functionality and/or tolerance to more severe challenges. The past two decades have witnessed an expanding recognition of the concept of hor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Edward J. Calabrese, Mark P. Mattson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1161ad0da01646da9a4bb362c47a85fa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1161ad0da01646da9a4bb362c47a85fa
record_format	dspace
spelling	oai:doaj.org-article:1161ad0da01646da9a4bb362c47a85fa2021-12-02T13:41:46ZHow does hormesis impact biology, toxicology, and medicine?10.1038/s41514-017-0013-z2056-3973https://doaj.org/article/1161ad0da01646da9a4bb362c47a85fa2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0013-zhttps://doaj.org/toc/2056-3973Abstract Hormesis refers to adaptive responses of biological systems to moderate environmental or self-imposed challenges through which the system improves its functionality and/or tolerance to more severe challenges. The past two decades have witnessed an expanding recognition of the concept of hormesis, elucidation of its evolutionary foundations, and underlying cellular and molecular mechanisms, and practical applications to improve quality of life. To better inform future basic and applied research, we organized and re-evaluated recent hormesis-related findings with the intent of incorporating new knowledge of biological mechanisms, and providing fundamental insights into the biological, biomedical and risk assessment implications of hormesis. As the literature on hormesis is expanding rapidly into new areas of basic and applied research, it is important to provide refined conceptualization of hormesis to aid in designing and interpreting future studies. Here, we establish a working compartmentalization of hormesis into ten categories that provide an integrated understanding of the biological meaning and applications of hormesis.Edward J. CalabreseMark P. MattsonNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Edward J. Calabrese Mark P. Mattson How does hormesis impact biology, toxicology, and medicine?
description	Abstract Hormesis refers to adaptive responses of biological systems to moderate environmental or self-imposed challenges through which the system improves its functionality and/or tolerance to more severe challenges. The past two decades have witnessed an expanding recognition of the concept of hormesis, elucidation of its evolutionary foundations, and underlying cellular and molecular mechanisms, and practical applications to improve quality of life. To better inform future basic and applied research, we organized and re-evaluated recent hormesis-related findings with the intent of incorporating new knowledge of biological mechanisms, and providing fundamental insights into the biological, biomedical and risk assessment implications of hormesis. As the literature on hormesis is expanding rapidly into new areas of basic and applied research, it is important to provide refined conceptualization of hormesis to aid in designing and interpreting future studies. Here, we establish a working compartmentalization of hormesis into ten categories that provide an integrated understanding of the biological meaning and applications of hormesis.
format	article
author	Edward J. Calabrese Mark P. Mattson
author_facet	Edward J. Calabrese Mark P. Mattson
author_sort	Edward J. Calabrese
title	How does hormesis impact biology, toxicology, and medicine?
title_short	How does hormesis impact biology, toxicology, and medicine?
title_full	How does hormesis impact biology, toxicology, and medicine?
title_fullStr	How does hormesis impact biology, toxicology, and medicine?
title_full_unstemmed	How does hormesis impact biology, toxicology, and medicine?
title_sort	how does hormesis impact biology, toxicology, and medicine?
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1161ad0da01646da9a4bb362c47a85fa
work_keys_str_mv	AT edwardjcalabrese howdoeshormesisimpactbiologytoxicologyandmedicine AT markpmattson howdoeshormesisimpactbiologytoxicologyandmedicine
_version_	1718392540013527040

How does hormesis impact biology, toxicology, and medicine?

Ejemplares similares