Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation

Aryl sulfonamides and sultams are important pharmacophores in medicinal chemistry. Here, the authors report a practical palladium-catalyzed C–H activation assisted by amino-acid residues in the substrate leading to arylsulfonamides and bioactive peptidosulfonamide macrocycles.

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Autores principales:	Jian Tang, Hongfei Chen, Yadong He, Wangjian Sheng, Qingqing Bai, Huan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1164417d0443466dbfc3306107b2bac4
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spelling	oai:doaj.org-article:1164417d0443466dbfc3306107b2bac42021-12-02T15:34:22ZPeptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation10.1038/s41467-018-05440-w2041-1723https://doaj.org/article/1164417d0443466dbfc3306107b2bac42018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05440-whttps://doaj.org/toc/2041-1723Aryl sulfonamides and sultams are important pharmacophores in medicinal chemistry. Here, the authors report a practical palladium-catalyzed C–H activation assisted by amino-acid residues in the substrate leading to arylsulfonamides and bioactive peptidosulfonamide macrocycles.Jian TangHongfei ChenYadong HeWangjian ShengQingqing BaiHuan WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jian Tang Hongfei Chen Yadong He Wangjian Sheng Qingqing Bai Huan Wang Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation
description	Aryl sulfonamides and sultams are important pharmacophores in medicinal chemistry. Here, the authors report a practical palladium-catalyzed C–H activation assisted by amino-acid residues in the substrate leading to arylsulfonamides and bioactive peptidosulfonamide macrocycles.
format	article
author	Jian Tang Hongfei Chen Yadong He Wangjian Sheng Qingqing Bai Huan Wang
author_facet	Jian Tang Hongfei Chen Yadong He Wangjian Sheng Qingqing Bai Huan Wang
author_sort	Jian Tang
title	Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation
title_short	Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation
title_full	Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation
title_fullStr	Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation
title_full_unstemmed	Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation
title_sort	peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by pd(ii)-catalyzed late-stage c–h activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1164417d0443466dbfc3306107b2bac4
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Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation

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