Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.

The objective of this study was to estimate influenza vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza during the 2011-2012 season in Japan using a test-negative case-control study design. The effect of co-circulating non-influenza respiratory viruses (NIRVs) on...

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Autores principales:	Motoi Suzuki, Le Nhat Minh, Hiroyuki Yoshimine, Kenichiro Inoue, Lay Myint Yoshida, Konosuke Morimoto, Koya Ariyoshi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/11668d893be248129751e4f8b6c66b56
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spelling	oai:doaj.org-article:11668d893be248129751e4f8b6c66b562021-11-18T08:32:36ZVaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.1932-620310.1371/journal.pone.0088813https://doaj.org/article/11668d893be248129751e4f8b6c66b562014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24551167/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The objective of this study was to estimate influenza vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza during the 2011-2012 season in Japan using a test-negative case-control study design. The effect of co-circulating non-influenza respiratory viruses (NIRVs) on VE estimates was also explored. Nasopharyngeal swab samples were collected from outpatients with influenza-like illnesses (ILIs) in a community hospital in Nagasaki, Japan. Thirteen respiratory viruses (RVs), including influenza A and B, were identified from the samples using a multiplex polymerase chain reaction. The difference in VE point estimates was assessed using three different controls: ILI patients that tested negative for influenza, those that tested negative for all RVs, and those that tested positive for NIRVs. The adjusted VE against medically attended, laboratory-confirmed influenza using all influenza-negative controls was 5.3% (95% confidence interval [CI], -60.5 to 44.1). The adjusted VEs using RV-negative and NIRV-positive controls were -1.5% (95% CI, -74.7 to 41) and 50% (95% CI, -43.2 to 82.5), respectively. Influenza VE was limited in Japan during the 2011-2012 season. Although the evidence is not conclusive, co-circulating NIRVs may affect influenza VE estimates in test-negative case-control studies.Motoi SuzukiLe Nhat MinhHiroyuki YoshimineKenichiro InoueLay Myint YoshidaKonosuke MorimotoKoya AriyoshiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88813 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Motoi Suzuki Le Nhat Minh Hiroyuki Yoshimine Kenichiro Inoue Lay Myint Yoshida Konosuke Morimoto Koya Ariyoshi Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.
description	The objective of this study was to estimate influenza vaccine effectiveness (VE) against medically attended, laboratory-confirmed influenza during the 2011-2012 season in Japan using a test-negative case-control study design. The effect of co-circulating non-influenza respiratory viruses (NIRVs) on VE estimates was also explored. Nasopharyngeal swab samples were collected from outpatients with influenza-like illnesses (ILIs) in a community hospital in Nagasaki, Japan. Thirteen respiratory viruses (RVs), including influenza A and B, were identified from the samples using a multiplex polymerase chain reaction. The difference in VE point estimates was assessed using three different controls: ILI patients that tested negative for influenza, those that tested negative for all RVs, and those that tested positive for NIRVs. The adjusted VE against medically attended, laboratory-confirmed influenza using all influenza-negative controls was 5.3% (95% confidence interval [CI], -60.5 to 44.1). The adjusted VEs using RV-negative and NIRV-positive controls were -1.5% (95% CI, -74.7 to 41) and 50% (95% CI, -43.2 to 82.5), respectively. Influenza VE was limited in Japan during the 2011-2012 season. Although the evidence is not conclusive, co-circulating NIRVs may affect influenza VE estimates in test-negative case-control studies.
format	article
author	Motoi Suzuki Le Nhat Minh Hiroyuki Yoshimine Kenichiro Inoue Lay Myint Yoshida Konosuke Morimoto Koya Ariyoshi
author_facet	Motoi Suzuki Le Nhat Minh Hiroyuki Yoshimine Kenichiro Inoue Lay Myint Yoshida Konosuke Morimoto Koya Ariyoshi
author_sort	Motoi Suzuki
title	Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.
title_short	Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.
title_full	Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.
title_fullStr	Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.
title_full_unstemmed	Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.
title_sort	vaccine effectiveness against medically attended laboratory-confirmed influenza in japan, 2011-2012 season.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/11668d893be248129751e4f8b6c66b56
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Vaccine effectiveness against medically attended laboratory-confirmed influenza in Japan, 2011-2012 Season.

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