HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation

HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmissionin vitro, and increases the number of infected clo...

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Autores principales:	Florent Percher, Céline Curis, Eléonore Pérès, Maria Artesi, Nicolas Rosewick, Patricia Jeannin, Antoine Gessain, Olivier Gout, Renaud Mahieux, Pierre-Emmanuel Ceccaldi, Anne Van den Broeke, Madeleine Duc Dodon, Philippe V. Afonso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1167d60565c44e4ab9d3cbfe88329a71
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spelling	oai:doaj.org-article:1167d60565c44e4ab9d3cbfe88329a712021-12-02T14:42:25ZHTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation10.1038/ncomms158902041-1723https://doaj.org/article/1167d60565c44e4ab9d3cbfe88329a712017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15890https://doaj.org/toc/2041-1723HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmissionin vitro, and increases the number of infected clones in mice.Florent PercherCéline CurisEléonore PérèsMaria ArtesiNicolas RosewickPatricia JeanninAntoine GessainOlivier GoutRenaud MahieuxPierre-Emmanuel CeccaldiAnne Van den BroekeMadeleine Duc DodonPhilippe V. AfonsoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florent Percher Céline Curis Eléonore Pérès Maria Artesi Nicolas Rosewick Patricia Jeannin Antoine Gessain Olivier Gout Renaud Mahieux Pierre-Emmanuel Ceccaldi Anne Van den Broeke Madeleine Duc Dodon Philippe V. Afonso HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
description	HTLV-1 predominantly spreads through direct cell-cell contacts, but mechanisms of target cell recruitment are unclear. Here, the authors show that HTLV-1 infected T-cells secrete leukotriene B4, which recruits T-cells, facilitates HTLV-1 transmissionin vitro, and increases the number of infected clones in mice.
format	article
author	Florent Percher Céline Curis Eléonore Pérès Maria Artesi Nicolas Rosewick Patricia Jeannin Antoine Gessain Olivier Gout Renaud Mahieux Pierre-Emmanuel Ceccaldi Anne Van den Broeke Madeleine Duc Dodon Philippe V. Afonso
author_facet	Florent Percher Céline Curis Eléonore Pérès Maria Artesi Nicolas Rosewick Patricia Jeannin Antoine Gessain Olivier Gout Renaud Mahieux Pierre-Emmanuel Ceccaldi Anne Van den Broeke Madeleine Duc Dodon Philippe V. Afonso
author_sort	Florent Percher
title	HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
title_short	HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
title_full	HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
title_fullStr	HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
title_full_unstemmed	HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation
title_sort	htlv-1-induced leukotriene b4 secretion by t cells promotes t cell recruitment and virus propagation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1167d60565c44e4ab9d3cbfe88329a71
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HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation

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