Risk factors for decreased bone mineral density in men with type 2 diabetes.

BACKGROUND: Type 2 diabetes and osteoporosis are widespread diseases in the middle-aged and elderly people. Most studies of osteoporosis in patients with type 2 diabetes have been performed in women; meantime risk factors for lowering bone mineral density (BMD) in men have been little studied.AIMS:...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Olga N. Fazullina, Anton I. Korbut, Maksim V. Dashkin, Vadim V. Klimontov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2021
Materias:	type 2 diabetes osteoporosis obesity adipose tissue testosterone vitamin d. Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/116a6321baa34e42b3b29f4a8e9a994b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:116a6321baa34e42b3b29f4a8e9a994b
record_format	dspace
spelling	oai:doaj.org-article:116a6321baa34e42b3b29f4a8e9a994b2021-11-14T09:00:23ZRisk factors for decreased bone mineral density in men with type 2 diabetes.2072-03512072-037810.14341/DM12383https://doaj.org/article/116a6321baa34e42b3b29f4a8e9a994b2021-01-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/12383https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378BACKGROUND: Type 2 diabetes and osteoporosis are widespread diseases in the middle-aged and elderly people. Most studies of osteoporosis in patients with type 2 diabetes have been performed in women; meantime risk factors for lowering bone mineral density (BMD) in men have been little studied.AIMS: to identify risk factors for decreased BMD at the lumbar spine, femoral neck and forearm in men with type 2 diabetes.METHODS: Eighty two men from 50 to 75 years old, with duration of diabetes for at least one year, were included in the study. Individuals with known risk factors for secondary osteoporosis were not included. Twenty-three men with normal BMD having no diabetes or obesity were acted as control. The T-score at the lumbar spine, femoral neck and forearm of a non-dominant arm, as well as body composition parameters, were evaluated by dual-energy X-ray absorptiometry. The levels of hormones that affect bone metabolism (parathyroid hormone, free testosterone, 25-OH vitamin D) were measured in blood serum by ELISA. Risk factors for reducing BMD were identified using multivariate regression analysis and receiver operating characteristic (ROC) curves.RESULTS: Among patients with diabetes, 49 individuals had normal BMD and 33 showed decreased T-score values (<-1 SD). Free testosterone <5.92 pg/ml was predictor for decreased BMD at the lumbar spine (OR=4.4, p=0.04). For femoral neck, the risk factors were body weight <95.5 kg (OR=2.8, p=0.04), total fat mass <27 kg (OR=3.3, p=0.03), truncal fat mass<17.5 kg(OR=4.5, p=0.006), android (central abdominal) fat mass <3.2 kg(OR=4.0, p=0.01), gynoid (hip) fat mass <3.5 kg(OR=3.3, p=0.02), and lean mass <59 kg(OR=3.0, p=0.04). Risk factors for reduced BMD at the forearm were diabetes duration>15.5 years (OR=3.7, p=0.03) and HbA1c <8.15% (OR=3.8, p=0.03). Parathyroid hormone and 25-OH-vitamin D did not predict BMD independently.CONCLUSIONS: In men with type 2 diabetes, low free testosterone is a risk factor for decreased BMD in the lumbar spine, and diabetes duration is a risk factor for decreased BMD in the forearm. The presence of obesity is associated with an increase in BMD in the femoral neck; a high HbA1c is associated with an increase in BMD in the forearm.Olga N. FazullinaAnton I. KorbutMaksim V. DashkinVadim V. KlimontovEndocrinology Research Centrearticletype 2 diabetesosteoporosisobesityadipose tissuetestosteronevitamin d.Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 23, Iss 5, Pp 424-433 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes osteoporosis obesity adipose tissue testosterone vitamin d. Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes osteoporosis obesity adipose tissue testosterone vitamin d. Nutritional diseases. Deficiency diseases RC620-627 Olga N. Fazullina Anton I. Korbut Maksim V. Dashkin Vadim V. Klimontov Risk factors for decreased bone mineral density in men with type 2 diabetes.
description	BACKGROUND: Type 2 diabetes and osteoporosis are widespread diseases in the middle-aged and elderly people. Most studies of osteoporosis in patients with type 2 diabetes have been performed in women; meantime risk factors for lowering bone mineral density (BMD) in men have been little studied.AIMS: to identify risk factors for decreased BMD at the lumbar spine, femoral neck and forearm in men with type 2 diabetes.METHODS: Eighty two men from 50 to 75 years old, with duration of diabetes for at least one year, were included in the study. Individuals with known risk factors for secondary osteoporosis were not included. Twenty-three men with normal BMD having no diabetes or obesity were acted as control. The T-score at the lumbar spine, femoral neck and forearm of a non-dominant arm, as well as body composition parameters, were evaluated by dual-energy X-ray absorptiometry. The levels of hormones that affect bone metabolism (parathyroid hormone, free testosterone, 25-OH vitamin D) were measured in blood serum by ELISA. Risk factors for reducing BMD were identified using multivariate regression analysis and receiver operating characteristic (ROC) curves.RESULTS: Among patients with diabetes, 49 individuals had normal BMD and 33 showed decreased T-score values (<-1 SD). Free testosterone <5.92 pg/ml was predictor for decreased BMD at the lumbar spine (OR=4.4, p=0.04). For femoral neck, the risk factors were body weight <95.5 kg (OR=2.8, p=0.04), total fat mass <27 kg (OR=3.3, p=0.03), truncal fat mass<17.5 kg(OR=4.5, p=0.006), android (central abdominal) fat mass <3.2 kg(OR=4.0, p=0.01), gynoid (hip) fat mass <3.5 kg(OR=3.3, p=0.02), and lean mass <59 kg(OR=3.0, p=0.04). Risk factors for reduced BMD at the forearm were diabetes duration>15.5 years (OR=3.7, p=0.03) and HbA1c <8.15% (OR=3.8, p=0.03). Parathyroid hormone and 25-OH-vitamin D did not predict BMD independently.CONCLUSIONS: In men with type 2 diabetes, low free testosterone is a risk factor for decreased BMD in the lumbar spine, and diabetes duration is a risk factor for decreased BMD in the forearm. The presence of obesity is associated with an increase in BMD in the femoral neck; a high HbA1c is associated with an increase in BMD in the forearm.
format	article
author	Olga N. Fazullina Anton I. Korbut Maksim V. Dashkin Vadim V. Klimontov
author_facet	Olga N. Fazullina Anton I. Korbut Maksim V. Dashkin Vadim V. Klimontov
author_sort	Olga N. Fazullina
title	Risk factors for decreased bone mineral density in men with type 2 diabetes.
title_short	Risk factors for decreased bone mineral density in men with type 2 diabetes.
title_full	Risk factors for decreased bone mineral density in men with type 2 diabetes.
title_fullStr	Risk factors for decreased bone mineral density in men with type 2 diabetes.
title_full_unstemmed	Risk factors for decreased bone mineral density in men with type 2 diabetes.
title_sort	risk factors for decreased bone mineral density in men with type 2 diabetes.
publisher	Endocrinology Research Centre
publishDate	2021
url	https://doaj.org/article/116a6321baa34e42b3b29f4a8e9a994b
work_keys_str_mv	AT olganfazullina riskfactorsfordecreasedbonemineraldensityinmenwithtype2diabetes AT antonikorbut riskfactorsfordecreasedbonemineraldensityinmenwithtype2diabetes AT maksimvdashkin riskfactorsfordecreasedbonemineraldensityinmenwithtype2diabetes AT vadimvklimontov riskfactorsfordecreasedbonemineraldensityinmenwithtype2diabetes
_version_	1718429449845735424

Risk factors for decreased bone mineral density in men with type 2 diabetes.

Ejemplares similares