Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.

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Autores principales:	Yun Zhao, Rachid Zagani, Sung-Moo Park, Naohiro Yoshida, Pankaj Shah, Hans-Christian Reinecker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/116dd64c0f8148448455c70c181f4b02
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spelling	oai:doaj.org-article:116dd64c0f8148448455c70c181f4b022021-12-02T16:57:44ZMicrobial recognition by GEF-H1 controls IKKε mediated activation of IRF510.1038/s41467-019-09283-x2041-1723https://doaj.org/article/116dd64c0f8148448455c70c181f4b022019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09283-xhttps://doaj.org/toc/2041-1723The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.Yun ZhaoRachid ZaganiSung-Moo ParkNaohiro YoshidaPankaj ShahHans-Christian ReineckerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yun Zhao Rachid Zagani Sung-Moo Park Naohiro Yoshida Pankaj Shah Hans-Christian Reinecker Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
description	The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKε.
format	article
author	Yun Zhao Rachid Zagani Sung-Moo Park Naohiro Yoshida Pankaj Shah Hans-Christian Reinecker
author_facet	Yun Zhao Rachid Zagani Sung-Moo Park Naohiro Yoshida Pankaj Shah Hans-Christian Reinecker
author_sort	Yun Zhao
title	Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_short	Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_full	Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_fullStr	Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_full_unstemmed	Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5
title_sort	microbial recognition by gef-h1 controls ikkε mediated activation of irf5
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/116dd64c0f8148448455c70c181f4b02
work_keys_str_mv	AT yunzhao microbialrecognitionbygefh1controlsikkemediatedactivationofirf5 AT rachidzagani microbialrecognitionbygefh1controlsikkemediatedactivationofirf5 AT sungmoopark microbialrecognitionbygefh1controlsikkemediatedactivationofirf5 AT naohiroyoshida microbialrecognitionbygefh1controlsikkemediatedactivationofirf5 AT pankajshah microbialrecognitionbygefh1controlsikkemediatedactivationofirf5 AT hanschristianreinecker microbialrecognitionbygefh1controlsikkemediatedactivationofirf5
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Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5

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