AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability

The biogenesis of AMPA-type glutamate receptor (AMPAR) complexes is only partially understood. Here the authors identify transient assemblies of GluA1-4 proteins and proteins FRRS1l/CPT1c that drive formation of mature AMPAR complexes in the ER. Mutations in FRRS1l are associated with intellectual d...

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Autores principales: Aline Brechet, Rebecca Buchert, Jochen Schwenk, Sami Boudkkazi, Gerd Zolles, Karine Siquier-Pernet, Irene Schaber, Wolfgang Bildl, Abdelkrim Saadi, Christine Bole-Feysot, Patrick Nitschke, Andre Reis, Heinrich Sticht, Nouriya Al-Sanna’a, Arndt Rolfs, Akos Kulik, Uwe Schulte, Laurence Colleaux, Rami Abou Jamra, Bernd Fakler
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/116ddb4d6f1445d88b45bc7aa135638e
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spelling oai:doaj.org-article:116ddb4d6f1445d88b45bc7aa135638e2021-12-02T17:06:21ZAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability10.1038/ncomms159102041-1723https://doaj.org/article/116ddb4d6f1445d88b45bc7aa135638e2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15910https://doaj.org/toc/2041-1723The biogenesis of AMPA-type glutamate receptor (AMPAR) complexes is only partially understood. Here the authors identify transient assemblies of GluA1-4 proteins and proteins FRRS1l/CPT1c that drive formation of mature AMPAR complexes in the ER. Mutations in FRRS1l are associated with intellectual disability and epilepsy in three families.Aline BrechetRebecca BuchertJochen SchwenkSami BoudkkaziGerd ZollesKarine Siquier-PernetIrene SchaberWolfgang BildlAbdelkrim SaadiChristine Bole-FeysotPatrick NitschkeAndre ReisHeinrich StichtNouriya Al-Sanna’aArndt RolfsAkos KulikUwe SchulteLaurence ColleauxRami Abou JamraBernd FaklerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Aline Brechet
Rebecca Buchert
Jochen Schwenk
Sami Boudkkazi
Gerd Zolles
Karine Siquier-Pernet
Irene Schaber
Wolfgang Bildl
Abdelkrim Saadi
Christine Bole-Feysot
Patrick Nitschke
Andre Reis
Heinrich Sticht
Nouriya Al-Sanna’a
Arndt Rolfs
Akos Kulik
Uwe Schulte
Laurence Colleaux
Rami Abou Jamra
Bernd Fakler
AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
description The biogenesis of AMPA-type glutamate receptor (AMPAR) complexes is only partially understood. Here the authors identify transient assemblies of GluA1-4 proteins and proteins FRRS1l/CPT1c that drive formation of mature AMPAR complexes in the ER. Mutations in FRRS1l are associated with intellectual disability and epilepsy in three families.
format article
author Aline Brechet
Rebecca Buchert
Jochen Schwenk
Sami Boudkkazi
Gerd Zolles
Karine Siquier-Pernet
Irene Schaber
Wolfgang Bildl
Abdelkrim Saadi
Christine Bole-Feysot
Patrick Nitschke
Andre Reis
Heinrich Sticht
Nouriya Al-Sanna’a
Arndt Rolfs
Akos Kulik
Uwe Schulte
Laurence Colleaux
Rami Abou Jamra
Bernd Fakler
author_facet Aline Brechet
Rebecca Buchert
Jochen Schwenk
Sami Boudkkazi
Gerd Zolles
Karine Siquier-Pernet
Irene Schaber
Wolfgang Bildl
Abdelkrim Saadi
Christine Bole-Feysot
Patrick Nitschke
Andre Reis
Heinrich Sticht
Nouriya Al-Sanna’a
Arndt Rolfs
Akos Kulik
Uwe Schulte
Laurence Colleaux
Rami Abou Jamra
Bernd Fakler
author_sort Aline Brechet
title AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
title_short AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
title_full AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
title_fullStr AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
title_full_unstemmed AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
title_sort ampa-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/116ddb4d6f1445d88b45bc7aa135638e
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