Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer

Zhen Wang,&ast; Tang-Ming Mo,&ast; Lei Tian, Jun-Qiang Chen Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China&ast;These authors contributed equally to this wor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang Z, Mo TM, Tian L, Chen JQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	gastric cancer tumor marker gastrin diagnosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/11714ecfd4964ba397745d2fab767384
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:11714ecfd4964ba397745d2fab767384
record_format	dspace
spelling	oai:doaj.org-article:11714ecfd4964ba397745d2fab7673842021-11-11T18:22:26ZGastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer1178-7074https://doaj.org/article/11714ecfd4964ba397745d2fab7673842021-11-01T00:00:00Zhttps://www.dovepress.com/gastrin-17-combined-with-cea-ca12-5-and-ca19-9-improves-the-sensitivit-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Zhen Wang,&ast; Tang-Ming Mo,&ast; Lei Tian, Jun-Qiang Chen Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun-Qiang Chen; Zhen Wang Email gxhans@163.com; wangzhensurgeon@163.comBackground: Previous studies reported the utility of serum tumor markers (such as CEA, CA12-5 and CA19-9) and gastrin-17 in the diagnosis of gastric cancer (GC). However, the value of these serum markers for diagnosing GC is still under debate. In this study, we aimed to evaluate the effect of gastrin-17, CEA, CA12-5 and CA19-9 in the diagnosis of GC.Methods: The level of CEA, CA12-5, CA19-9 and gastrin-17 was tested in 230 GC patients and 99 healthy people. The value of the four markers for diagnosing GC was analyzed.Results: The positive rate of Gastrin-17, CEA, CA19-9 and CA12-5 was much higher in GC group (22.61%, 22.61%, 20.00% and 8.26%, respectively) than that of healthy control group (5.05%, 2.02%, 1.01% and 2.02%, respectively). The sensitivity of Gastrin-17, CEA, CA12-5 and CA19-9 in the diagnosis of GC was 22.61%, 22.61%, 6.96% and 20.00%, respectively, and the corresponding specificity was 94.95%, 97.98%, 98.99% and 98.99%, respectively. By using the optimal cut-off value derived from the area under curve (AUC) of receiver operating characteristic curve, the AUC of gastrin-17, CEA, CA12-5, CA19-9 increased to 0.72, 0.64, 0.61 and 0.65, respectively. After combining the four markers, the AUC increased to 0.79 (95% CI: 0.75– 0.84), and the corresponding sensitivity and specificity were 65.22% (95% CI: 58.70– 71.40%) and 84.85% (95% CI: 76.20– 91.30%), respectively, which were significantly higher than those of separate markers (P < 0.05).Conclusion: CEA, CA12-5, CA19-9 and gastrin-17 were all valuable in the diagnosis of GC, and gastrin-17 had the best diagnostic value among the four markers. Gastrin-17 combined with CEA, CA12-5 and CA19-9 could improve the diagnostic value of GC significantly. Prospective, multi-center studies are needed to validate our findings.Keywords: gastric cancer, tumor marker, gastrin, diagnosisWang ZMo TMTian LChen JQDove Medical Pressarticlegastric cancertumor markergastrindiagnosisMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8087-8095 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer tumor marker gastrin diagnosis Medicine (General) R5-920
spellingShingle	gastric cancer tumor marker gastrin diagnosis Medicine (General) R5-920 Wang Z Mo TM Tian L Chen JQ Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer
description	Zhen Wang,&ast; Tang-Ming Mo,&ast; Lei Tian, Jun-Qiang Chen Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun-Qiang Chen; Zhen Wang Email gxhans@163.com; wangzhensurgeon@163.comBackground: Previous studies reported the utility of serum tumor markers (such as CEA, CA12-5 and CA19-9) and gastrin-17 in the diagnosis of gastric cancer (GC). However, the value of these serum markers for diagnosing GC is still under debate. In this study, we aimed to evaluate the effect of gastrin-17, CEA, CA12-5 and CA19-9 in the diagnosis of GC.Methods: The level of CEA, CA12-5, CA19-9 and gastrin-17 was tested in 230 GC patients and 99 healthy people. The value of the four markers for diagnosing GC was analyzed.Results: The positive rate of Gastrin-17, CEA, CA19-9 and CA12-5 was much higher in GC group (22.61%, 22.61%, 20.00% and 8.26%, respectively) than that of healthy control group (5.05%, 2.02%, 1.01% and 2.02%, respectively). The sensitivity of Gastrin-17, CEA, CA12-5 and CA19-9 in the diagnosis of GC was 22.61%, 22.61%, 6.96% and 20.00%, respectively, and the corresponding specificity was 94.95%, 97.98%, 98.99% and 98.99%, respectively. By using the optimal cut-off value derived from the area under curve (AUC) of receiver operating characteristic curve, the AUC of gastrin-17, CEA, CA12-5, CA19-9 increased to 0.72, 0.64, 0.61 and 0.65, respectively. After combining the four markers, the AUC increased to 0.79 (95% CI: 0.75– 0.84), and the corresponding sensitivity and specificity were 65.22% (95% CI: 58.70– 71.40%) and 84.85% (95% CI: 76.20– 91.30%), respectively, which were significantly higher than those of separate markers (P < 0.05).Conclusion: CEA, CA12-5, CA19-9 and gastrin-17 were all valuable in the diagnosis of GC, and gastrin-17 had the best diagnostic value among the four markers. Gastrin-17 combined with CEA, CA12-5 and CA19-9 could improve the diagnostic value of GC significantly. Prospective, multi-center studies are needed to validate our findings.Keywords: gastric cancer, tumor marker, gastrin, diagnosis
format	article
author	Wang Z Mo TM Tian L Chen JQ
author_facet	Wang Z Mo TM Tian L Chen JQ
author_sort	Wang Z
title	Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer
title_short	Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer
title_full	Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer
title_fullStr	Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer
title_full_unstemmed	Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer
title_sort	gastrin-17 combined with cea, ca12-5 and ca19-9 improves the sensitivity for the diagnosis of gastric cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/11714ecfd4964ba397745d2fab767384
work_keys_str_mv	AT wangz gastrin17combinedwithceaca125andca199improvesthesensitivityforthediagnosisofgastriccancer AT motm gastrin17combinedwithceaca125andca199improvesthesensitivityforthediagnosisofgastriccancer AT tianl gastrin17combinedwithceaca125andca199improvesthesensitivityforthediagnosisofgastriccancer AT chenjq gastrin17combinedwithceaca125andca199improvesthesensitivityforthediagnosisofgastriccancer
_version_	1718431806408097792

Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer

Ejemplares similares