Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior

Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior

The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.

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Autores principales: J. Blaze, A. Navickas, H. L. Phillips, S. Heissel, A. Plaza-Jennings, S. Miglani, H. Asgharian, M. Foo, C. D. Katanski, C. P. Watkins, Z. T. Pennington, B. Javidfar, S. Espeso-Gil, B. Rostandy, H. Alwaseem, C. G. Hahn, H. Molina, D. J. Cai, T. Pan, W. D. Yao, H. Goodarzi, F. Haghighi, S. Akbarian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/1173a6a94f8242d29268837ba49a821d
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spelling oai:doaj.org-article:1173a6a94f8242d29268837ba49a821d2021-12-02T16:28:51ZNeuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior10.1038/s41467-021-24969-x2041-1723https://doaj.org/article/1173a6a94f8242d29268837ba49a821d2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24969-xhttps://doaj.org/toc/2041-1723The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.J. BlazeA. NavickasH. L. PhillipsS. HeisselA. Plaza-JenningsS. MiglaniH. AsgharianM. FooC. D. KatanskiC. P. WatkinsZ. T. PenningtonB. JavidfarS. Espeso-GilB. RostandyH. AlwaseemC. G. HahnH. MolinaD. J. CaiT. PanW. D. YaoH. GoodarziF. HaghighiS. AkbarianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
J. Blaze
A. Navickas
H. L. Phillips
S. Heissel
A. Plaza-Jennings
S. Miglani
H. Asgharian
M. Foo
C. D. Katanski
C. P. Watkins
Z. T. Pennington
B. Javidfar
S. Espeso-Gil
B. Rostandy
H. Alwaseem
C. G. Hahn
H. Molina
D. J. Cai
T. Pan
W. D. Yao
H. Goodarzi
F. Haghighi
S. Akbarian
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
description The link between tRNA modifications, protein translation, and behavior is unclear. Here, the authors show that neuronal Nsun2 deficiency results in codon-specific epitranscriptomic changes of Gly-tRNAs and proteomic changes affecting synaptic signaling and behavior in mice.
format article
author J. Blaze
A. Navickas
H. L. Phillips
S. Heissel
A. Plaza-Jennings
S. Miglani
H. Asgharian
M. Foo
C. D. Katanski
C. P. Watkins
Z. T. Pennington
B. Javidfar
S. Espeso-Gil
B. Rostandy
H. Alwaseem
C. G. Hahn
H. Molina
D. J. Cai
T. Pan
W. D. Yao
H. Goodarzi
F. Haghighi
S. Akbarian
author_facet J. Blaze
A. Navickas
H. L. Phillips
S. Heissel
A. Plaza-Jennings
S. Miglani
H. Asgharian
M. Foo
C. D. Katanski
C. P. Watkins
Z. T. Pennington
B. Javidfar
S. Espeso-Gil
B. Rostandy
H. Alwaseem
C. G. Hahn
H. Molina
D. J. Cai
T. Pan
W. D. Yao
H. Goodarzi
F. Haghighi
S. Akbarian
author_sort J. Blaze
title Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
title_short Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
title_full Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
title_fullStr Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
title_full_unstemmed Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
title_sort neuronal nsun2 deficiency produces trna epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/1173a6a94f8242d29268837ba49a821d
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