Protective Efficacy in a Hamster Model of a Multivalent Vaccine for Human Visceral Leishmaniasis (MuLeVaClin) Consisting of the KMP11, LEISH-F3+, and LJL143 Antigens in Virosomes, Plus GLA-SE Adjuvant

Protective Efficacy in a Hamster Model of a Multivalent Vaccine for Human Visceral Leishmaniasis (MuLeVaClin) Consisting of the KMP11, LEISH-F3+, and LJL143 Antigens in Virosomes, Plus GLA-SE Adjuvant

Visceral leishmaniasis (VL) is the most severe clinical form of leishmaniasis, fatal if untreated. Vaccination is the most cost-effective approach to disease control; however, to date, no vaccines against human VL have been made available. This work examines the efficacy of a novel vaccine consistin...

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Autores principales: Laura Fernández, Jose Carlos Solana, Carmen Sánchez, Mª Ángeles Jiménez, Jose M. Requena, Rhea Coler, Steven G. Reed, Jesus G. Valenzuela, Shaden Kamhawi, Fabiano Oliveira, Epifanio Fichera, Reinhard Glueck, Maria Elena Bottazzi, Gaurav Gupta, Pedro Cecilio, Begoña Pérez-Cabezas, Anabela Cordeiro-da-Silva, Luigi Gradoni, Eugenia Carrillo, Javier Moreno
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
leishmaniasis
hamster
vaccine
virosomes
KMP11
LEISH-F3
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/117c18657fb5436286218190c48f7d64
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