Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease

Background: This study aimed at evaluating oxidant and antioxidant markers (including nitrite, nitrate, total antioxidant capacity(TAC), malondialdehyde (MDA), iron, selenium, glutathione peroxidase (GPx), and glutathione reductase (GR) in patients withinflammatory bowel disease (IBD) and compare th...

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Autores principales:	Erfan Mohammadi, Durdi Qujeq, Hassan Taheri, Karimollah Hajian-Tilaki
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2018
Materias:	nitrites nitrates antioxidants malondialdehyde iron selenium glutathione peroxidase glutathione reductase Medicine R
Acceso en línea:	https://doaj.org/article/1182522d0fdf40f78c1e8111a3e53430
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spelling	oai:doaj.org-article:1182522d0fdf40f78c1e8111a3e534302021-11-20T07:10:16ZInappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease2783-2430https://doaj.org/article/1182522d0fdf40f78c1e8111a3e534302018-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_47165_745b6ceaab6fb0d41466596cb063b1df.pdfhttps://doaj.org/toc/2783-2430Background: This study aimed at evaluating oxidant and antioxidant markers (including nitrite, nitrate, total antioxidant capacity(TAC), malondialdehyde (MDA), iron, selenium, glutathione peroxidase (GPx), and glutathione reductase (GR) in patients withinflammatory bowel disease (IBD) and compare them with healthy controls.Methods: Serum samples were obtained from 35 patients (19 ulcerative colitis (UC) and 16 Crohn’s disease (CD) in the active phaseof the disease) and 30 healthy controls. Serum levels of nitrite and nitrate, TAC, MDA, iron, selenium, glutathione peroxidase, andglutathione reductase were measured. The results were compared between the two groups using independent t-student test. ThePearson’s correlation coefficient (for continuous data) was performed using the SPSS software.Results: Serum levels of nitrite, nitrate, and MDA were significantly higher (P = 0.001) in patients with IBD, while the levels of TAC,trace elements, glutathione peroxidase (GPx), and Glutathione Reductase (GR) levels were lower (P < 0.05) in patients with IBD.However, when females were considered separately, Gpx and GR activities were not significantly different in those with and withoutIBD. The present results showed that nitrite, MDA, GPx, GR, and Se: MDA ratio had the strongest correlation with disease activityscore.Conclusions: There is an imbalance between oxidant and antioxidant properties in patients with IBD, which highlights the role ofoxidative stress in the pathogenesis of this disease.Erfan MohammadiDurdi QujeqHassan TaheriKarimollah Hajian-TilakiShiraz University of Medical Sciencesarticlenitritesnitratesantioxidantsmalondialdehydeironseleniumglutathione peroxidaseglutathione reductaseMedicineRENIranian Journal of Colorectal Research, Vol 6, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nitrites nitrates antioxidants malondialdehyde iron selenium glutathione peroxidase glutathione reductase Medicine R
spellingShingle	nitrites nitrates antioxidants malondialdehyde iron selenium glutathione peroxidase glutathione reductase Medicine R Erfan Mohammadi Durdi Qujeq Hassan Taheri Karimollah Hajian-Tilaki Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease
description	Background: This study aimed at evaluating oxidant and antioxidant markers (including nitrite, nitrate, total antioxidant capacity(TAC), malondialdehyde (MDA), iron, selenium, glutathione peroxidase (GPx), and glutathione reductase (GR) in patients withinflammatory bowel disease (IBD) and compare them with healthy controls.Methods: Serum samples were obtained from 35 patients (19 ulcerative colitis (UC) and 16 Crohn’s disease (CD) in the active phaseof the disease) and 30 healthy controls. Serum levels of nitrite and nitrate, TAC, MDA, iron, selenium, glutathione peroxidase, andglutathione reductase were measured. The results were compared between the two groups using independent t-student test. ThePearson’s correlation coefficient (for continuous data) was performed using the SPSS software.Results: Serum levels of nitrite, nitrate, and MDA were significantly higher (P = 0.001) in patients with IBD, while the levels of TAC,trace elements, glutathione peroxidase (GPx), and Glutathione Reductase (GR) levels were lower (P < 0.05) in patients with IBD.However, when females were considered separately, Gpx and GR activities were not significantly different in those with and withoutIBD. The present results showed that nitrite, MDA, GPx, GR, and Se: MDA ratio had the strongest correlation with disease activityscore.Conclusions: There is an imbalance between oxidant and antioxidant properties in patients with IBD, which highlights the role ofoxidative stress in the pathogenesis of this disease.
format	article
author	Erfan Mohammadi Durdi Qujeq Hassan Taheri Karimollah Hajian-Tilaki
author_facet	Erfan Mohammadi Durdi Qujeq Hassan Taheri Karimollah Hajian-Tilaki
author_sort	Erfan Mohammadi
title	Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease
title_short	Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease
title_full	Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease
title_fullStr	Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease
title_full_unstemmed	Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease
title_sort	inappropriate total oxidant/antioxidant status, nitric oxide oxidation end products and trace element levels in patients with inflammatory bowel disease
publisher	Shiraz University of Medical Sciences
publishDate	2018
url	https://doaj.org/article/1182522d0fdf40f78c1e8111a3e53430
work_keys_str_mv	AT erfanmohammadi inappropriatetotaloxidantantioxidantstatusnitricoxideoxidationendproductsandtraceelementlevelsinpatientswithinflammatoryboweldisease AT durdiqujeq inappropriatetotaloxidantantioxidantstatusnitricoxideoxidationendproductsandtraceelementlevelsinpatientswithinflammatoryboweldisease AT hassantaheri inappropriatetotaloxidantantioxidantstatusnitricoxideoxidationendproductsandtraceelementlevelsinpatientswithinflammatoryboweldisease AT karimollahhajiantilaki inappropriatetotaloxidantantioxidantstatusnitricoxideoxidationendproductsandtraceelementlevelsinpatientswithinflammatoryboweldisease
_version_	1718419465097445376

Inappropriate Total Oxidant/Antioxidant Status, Nitric Oxide Oxidation End Products and Trace Element Levels in Patients with Inflammatory Bowel Disease

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