Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum

Abstract Background The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast As...

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Autores principales:	Afolabi Owoloye, Michael Olufemi, Emmanuel T. Idowu, Kolapo M. Oyebola
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Artemisinin-based combination therapy Partial resistance Plasmodium falciparum Kelch-13 Pfcoronin pfatpase6 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d44
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spelling	oai:doaj.org-article:118424902a0b4d6d95dcc1d5bc867d442021-12-05T12:21:33ZPrevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum10.1186/s12936-021-03987-61475-2875https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d442021-12-01T00:00:00Zhttps://doi.org/10.1186/s12936-021-03987-6https://doaj.org/toc/1475-2875Abstract Background The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards treatment failure. Monitoring the prevalence of mutations associated with artemisinin resistance in African populations is necessary to stop resistance in its tracks. Mutations in Plasmodium falciparum genes pfk13, pfcoronin and pfatpase6 have been linked with ART partial resistance. Methods Findings from published research articles on the prevalence of pfk13, pfcoronin and pfatpase6 polymorphisms in Africa were collated. PubMed, Embase and Google Scholar were searched for relevant articles reporting polymorphisms in these genes across Africa from 2014 to August 2021, for pfk13 and pfcoronin. For pfatpase6, relevant articles between 2003 and August 2021 were retrieved. Results Eighty-seven studies passed the inclusion criteria for this analysis and reported 742 single nucleotide polymorphisms in 37,864 P. falciparum isolates from 29 African countries. Five validated-pfk13 partial resistance markers were identified in Africa: R561H in Rwanda and Tanzania, M476I in Tanzania, F446I in Mali, C580Y in Ghana, and P553L in an Angolan isolate. In Tanzania, three (L263E, E431K, S769N) of the four mutations (L263E, E431K, A623E, S769N) in pfatpase6 gene associated with high in vitro IC50 were reported. pfcoronin polymorphisms were reported in Senegal, Gabon, Ghana, Kenya, and Congo, with P76S being the most prevalent mutation. Conclusions This meta-analysis provides an overview of the prevalence and widespread distribution of pfk13, pfcoronin and pfatpase6 mutations in Africa. Understanding the phenotypic consequences of these mutations can provide information on the efficacy status of artemisinin-based treatment of malaria across the continent. Graphical AbstractAfolabi OwoloyeMichael OlufemiEmmanuel T. IdowuKolapo M. OyebolaBMCarticleArtemisinin-based combination therapyPartial resistancePlasmodium falciparumKelch-13Pfcoroninpfatpase6Arctic medicine. Tropical medicineRC955-962Infectious and parasitic diseasesRC109-216ENMalaria Journal, Vol 20, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Artemisinin-based combination therapy Partial resistance Plasmodium falciparum Kelch-13 Pfcoronin pfatpase6 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216
spellingShingle	Artemisinin-based combination therapy Partial resistance Plasmodium falciparum Kelch-13 Pfcoronin pfatpase6 Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Afolabi Owoloye Michael Olufemi Emmanuel T. Idowu Kolapo M. Oyebola Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
description	Abstract Background The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However, the emergence of artemisinin (ART) partial resistance in Southeast Asia and emerging reports of delayed parasite sensitivity to ACT in African parasites signal a gradual trend towards treatment failure. Monitoring the prevalence of mutations associated with artemisinin resistance in African populations is necessary to stop resistance in its tracks. Mutations in Plasmodium falciparum genes pfk13, pfcoronin and pfatpase6 have been linked with ART partial resistance. Methods Findings from published research articles on the prevalence of pfk13, pfcoronin and pfatpase6 polymorphisms in Africa were collated. PubMed, Embase and Google Scholar were searched for relevant articles reporting polymorphisms in these genes across Africa from 2014 to August 2021, for pfk13 and pfcoronin. For pfatpase6, relevant articles between 2003 and August 2021 were retrieved. Results Eighty-seven studies passed the inclusion criteria for this analysis and reported 742 single nucleotide polymorphisms in 37,864 P. falciparum isolates from 29 African countries. Five validated-pfk13 partial resistance markers were identified in Africa: R561H in Rwanda and Tanzania, M476I in Tanzania, F446I in Mali, C580Y in Ghana, and P553L in an Angolan isolate. In Tanzania, three (L263E, E431K, S769N) of the four mutations (L263E, E431K, A623E, S769N) in pfatpase6 gene associated with high in vitro IC50 were reported. pfcoronin polymorphisms were reported in Senegal, Gabon, Ghana, Kenya, and Congo, with P76S being the most prevalent mutation. Conclusions This meta-analysis provides an overview of the prevalence and widespread distribution of pfk13, pfcoronin and pfatpase6 mutations in Africa. Understanding the phenotypic consequences of these mutations can provide information on the efficacy status of artemisinin-based treatment of malaria across the continent. Graphical Abstract
format	article
author	Afolabi Owoloye Michael Olufemi Emmanuel T. Idowu Kolapo M. Oyebola
author_facet	Afolabi Owoloye Michael Olufemi Emmanuel T. Idowu Kolapo M. Oyebola
author_sort	Afolabi Owoloye
title	Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
title_short	Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
title_full	Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
title_fullStr	Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
title_full_unstemmed	Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
title_sort	prevalence of potential mediators of artemisinin resistance in african isolates of plasmodium falciparum
publisher	BMC
publishDate	2021
url	https://doaj.org/article/118424902a0b4d6d95dcc1d5bc867d44
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Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum

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