Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)

Pathological angiogenesis is the hallmark of ischemic retinal diseases among them retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR). Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and a widely used model for ischemic retinopathies. We explore...

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Autores principales:	Maria Vähätupa, Niklas Salonen, Hannele Uusitalo-Järvinen, Tero A. H. Järvinen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vascular homing peptide cell penetrating peptide angiogenesis oxygen-induced retinopathy (OIR) retina diabetic retinopathy Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/11890a4f002747f4986ce99736e5812f
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spelling	oai:doaj.org-article:11890a4f002747f4986ce99736e5812f2021-11-25T18:42:03ZSelective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)10.3390/pharmaceutics131119321999-4923https://doaj.org/article/11890a4f002747f4986ce99736e5812f2021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1932https://doaj.org/toc/1999-4923Pathological angiogenesis is the hallmark of ischemic retinal diseases among them retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR). Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and a widely used model for ischemic retinopathies. We explored whether the vascular homing peptide CAR (CARSKNKDC) which recognizes angiogenic blood vessels can be used to target the retina in OIR. We were able to demonstrate that the systemically administered CAR vascular homing peptide homed selectively to the preretinal neovessels in OIR. As a cell and tissue-penetrating peptide, CAR also penetrated into the retina. Hyperoxia used to induce OIR in the retina also causes bronchopulmonary dysplasia in the lungs. We showed that the CAR peptide is not targeted to the lungs in normal mice but is targeted to the lungs after hyperoxia-/hypoxia-treatment of the animals. The site-specific delivery of the CAR peptide to the pathologic retinal vasculature and the penetration of the retinal tissue may offer new opportunities for treating retinopathies more selectively and with less side effects.Maria VähätupaNiklas SalonenHannele Uusitalo-JärvinenTero A. H. JärvinenMDPI AGarticlevascular homing peptidecell penetrating peptideangiogenesisoxygen-induced retinopathy (OIR)retinadiabetic retinopathyPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1932, p 1932 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular homing peptide cell penetrating peptide angiogenesis oxygen-induced retinopathy (OIR) retina diabetic retinopathy Pharmacy and materia medica RS1-441
spellingShingle	vascular homing peptide cell penetrating peptide angiogenesis oxygen-induced retinopathy (OIR) retina diabetic retinopathy Pharmacy and materia medica RS1-441 Maria Vähätupa Niklas Salonen Hannele Uusitalo-Järvinen Tero A. H. Järvinen Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)
description	Pathological angiogenesis is the hallmark of ischemic retinal diseases among them retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR). Oxygen-induced retinopathy (OIR) is a pure hypoxia-driven angiogenesis model and a widely used model for ischemic retinopathies. We explored whether the vascular homing peptide CAR (CARSKNKDC) which recognizes angiogenic blood vessels can be used to target the retina in OIR. We were able to demonstrate that the systemically administered CAR vascular homing peptide homed selectively to the preretinal neovessels in OIR. As a cell and tissue-penetrating peptide, CAR also penetrated into the retina. Hyperoxia used to induce OIR in the retina also causes bronchopulmonary dysplasia in the lungs. We showed that the CAR peptide is not targeted to the lungs in normal mice but is targeted to the lungs after hyperoxia-/hypoxia-treatment of the animals. The site-specific delivery of the CAR peptide to the pathologic retinal vasculature and the penetration of the retinal tissue may offer new opportunities for treating retinopathies more selectively and with less side effects.
format	article
author	Maria Vähätupa Niklas Salonen Hannele Uusitalo-Järvinen Tero A. H. Järvinen
author_facet	Maria Vähätupa Niklas Salonen Hannele Uusitalo-Järvinen Tero A. H. Järvinen
author_sort	Maria Vähätupa
title	Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)
title_short	Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)
title_full	Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)
title_fullStr	Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)
title_full_unstemmed	Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)
title_sort	selective targeting and tissue penetration to the retina by a systemically administered vascular homing peptide in oxygen induced retinopathy (oir)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/11890a4f002747f4986ce99736e5812f
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Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR)

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