Conformational pathway provides unique sensitivity to a synaptic mGluR

Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.

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Detalles Bibliográficos
Autores principales:	Chris H. Habrian, Joshua Levitz, Vojtech Vyklicky, Zhu Fu, Adam Hoagland, Isabelle McCort-Tranchepain, Francine Acher, Ehud Y. Isacoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/118cbbd567084baca674e6ab3894b693
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spelling	oai:doaj.org-article:118cbbd567084baca674e6ab3894b6932021-12-02T14:40:18ZConformational pathway provides unique sensitivity to a synaptic mGluR10.1038/s41467-019-13407-82041-1723https://doaj.org/article/118cbbd567084baca674e6ab3894b6932019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13407-8https://doaj.org/toc/2041-1723Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.Chris H. HabrianJoshua LevitzVojtech VyklickyZhu FuAdam HoaglandIsabelle McCort-TranchepainFrancine AcherEhud Y. IsacoffNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chris H. Habrian Joshua Levitz Vojtech Vyklicky Zhu Fu Adam Hoagland Isabelle McCort-Tranchepain Francine Acher Ehud Y. Isacoff Conformational pathway provides unique sensitivity to a synaptic mGluR
description	Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at neural synapses. Here authors use FRET assays in live cells to monitor mGluR2/7’s activation and reveal how heterodimerization can alter the glutamate response of an mGluR.
format	article
author	Chris H. Habrian Joshua Levitz Vojtech Vyklicky Zhu Fu Adam Hoagland Isabelle McCort-Tranchepain Francine Acher Ehud Y. Isacoff
author_facet	Chris H. Habrian Joshua Levitz Vojtech Vyklicky Zhu Fu Adam Hoagland Isabelle McCort-Tranchepain Francine Acher Ehud Y. Isacoff
author_sort	Chris H. Habrian
title	Conformational pathway provides unique sensitivity to a synaptic mGluR
title_short	Conformational pathway provides unique sensitivity to a synaptic mGluR
title_full	Conformational pathway provides unique sensitivity to a synaptic mGluR
title_fullStr	Conformational pathway provides unique sensitivity to a synaptic mGluR
title_full_unstemmed	Conformational pathway provides unique sensitivity to a synaptic mGluR
title_sort	conformational pathway provides unique sensitivity to a synaptic mglur
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/118cbbd567084baca674e6ab3894b693
work_keys_str_mv	AT chrishhabrian conformationalpathwayprovidesuniquesensitivitytoasynapticmglur AT joshualevitz conformationalpathwayprovidesuniquesensitivitytoasynapticmglur AT vojtechvyklicky conformationalpathwayprovidesuniquesensitivitytoasynapticmglur AT zhufu conformationalpathwayprovidesuniquesensitivitytoasynapticmglur AT adamhoagland conformationalpathwayprovidesuniquesensitivitytoasynapticmglur AT isabellemccorttranchepain conformationalpathwayprovidesuniquesensitivitytoasynapticmglur AT francineacher conformationalpathwayprovidesuniquesensitivitytoasynapticmglur AT ehudyisacoff conformationalpathwayprovidesuniquesensitivitytoasynapticmglur
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Conformational pathway provides unique sensitivity to a synaptic mGluR

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