Degree and site of chromosomal instability define its oncogenic potential

Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely dependent on both its extent and anatomical location.

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Autores principales:	Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c626
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spelling	oai:doaj.org-article:118f25f0a18f4b6ea689450fb6a3c6262021-12-02T17:32:57ZDegree and site of chromosomal instability define its oncogenic potential10.1038/s41467-020-15279-92041-1723https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c6262020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15279-9https://doaj.org/toc/2041-1723Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely dependent on both its extent and anatomical location.Wilma H. M. HoevenaarAniek JanssenAjit I. QuirindongoHuiying MaSjoerd J. KlaasenAntoinette TeixeiraBastiaan van GerwenNico LansuFolkert H. M. MorsinkG. Johan A. OfferhausRené H. MedemaGeert J. P. L. KopsNannette JellumaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wilma H. M. Hoevenaar Aniek Janssen Ajit I. Quirindongo Huiying Ma Sjoerd J. Klaasen Antoinette Teixeira Bastiaan van Gerwen Nico Lansu Folkert H. M. Morsink G. Johan A. Offerhaus René H. Medema Geert J. P. L. Kops Nannette Jelluma Degree and site of chromosomal instability define its oncogenic potential
description	Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely dependent on both its extent and anatomical location.
format	article
author	Wilma H. M. Hoevenaar Aniek Janssen Ajit I. Quirindongo Huiying Ma Sjoerd J. Klaasen Antoinette Teixeira Bastiaan van Gerwen Nico Lansu Folkert H. M. Morsink G. Johan A. Offerhaus René H. Medema Geert J. P. L. Kops Nannette Jelluma
author_facet	Wilma H. M. Hoevenaar Aniek Janssen Ajit I. Quirindongo Huiying Ma Sjoerd J. Klaasen Antoinette Teixeira Bastiaan van Gerwen Nico Lansu Folkert H. M. Morsink G. Johan A. Offerhaus René H. Medema Geert J. P. L. Kops Nannette Jelluma
author_sort	Wilma H. M. Hoevenaar
title	Degree and site of chromosomal instability define its oncogenic potential
title_short	Degree and site of chromosomal instability define its oncogenic potential
title_full	Degree and site of chromosomal instability define its oncogenic potential
title_fullStr	Degree and site of chromosomal instability define its oncogenic potential
title_full_unstemmed	Degree and site of chromosomal instability define its oncogenic potential
title_sort	degree and site of chromosomal instability define its oncogenic potential
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/118f25f0a18f4b6ea689450fb6a3c626
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Degree and site of chromosomal instability define its oncogenic potential

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