Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion

Glycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the trans- and cis-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neut...

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Autores principales:	Batuhan Kav, Bruno Demé, Christian Gege, Motomu Tanaka, Emanuel Schneck, Thomas R. Weikl
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	glycolipids carbohydrate–carbohydrate interactions LewisX carbohydrate membrane adhesion membrane shape fluctuations molecular dynamics (MD) simulations Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/118ff22e0fd94f2e9f3318ff46a3ac3c
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spelling	oai:doaj.org-article:118ff22e0fd94f2e9f3318ff46a3ac3c2021-11-19T07:55:41ZInterplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion2296-889X10.3389/fmolb.2021.754654https://doaj.org/article/118ff22e0fd94f2e9f3318ff46a3ac3c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.754654/fullhttps://doaj.org/toc/2296-889XGlycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the trans- and cis-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neutron scattering experiments. We find that the cis-interactions between glycolipids in the same membrane leaflet tend to strengthen the trans-interactions between glycolipids in apposing leaflets. The trans-interactions of the glycolipids in our simulations require local membrane separations that are significantly smaller than the average membrane separations in the neutron scattering experiments, which indicates an important role of membrane shape fluctuations in glycolipid trans-binding. Simulations at the experimentally measured average membrane separations provide a molecular picture of the interplay between glycolipid attraction and steric repulsion of the fluctuating membranes probed in the experiments.Batuhan KavBruno DeméChristian GegeMotomu TanakaMotomu TanakaEmanuel SchneckEmanuel SchneckThomas R. WeiklFrontiers Media S.A.articleglycolipidscarbohydrate–carbohydrate interactionsLewisX carbohydratemembrane adhesionmembrane shape fluctuationsmolecular dynamics (MD) simulationsBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glycolipids carbohydrate–carbohydrate interactions LewisX carbohydrate membrane adhesion membrane shape fluctuations molecular dynamics (MD) simulations Biology (General) QH301-705.5
spellingShingle	glycolipids carbohydrate–carbohydrate interactions LewisX carbohydrate membrane adhesion membrane shape fluctuations molecular dynamics (MD) simulations Biology (General) QH301-705.5 Batuhan Kav Bruno Demé Christian Gege Motomu Tanaka Motomu Tanaka Emanuel Schneck Emanuel Schneck Thomas R. Weikl Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion
description	Glycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the trans- and cis-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neutron scattering experiments. We find that the cis-interactions between glycolipids in the same membrane leaflet tend to strengthen the trans-interactions between glycolipids in apposing leaflets. The trans-interactions of the glycolipids in our simulations require local membrane separations that are significantly smaller than the average membrane separations in the neutron scattering experiments, which indicates an important role of membrane shape fluctuations in glycolipid trans-binding. Simulations at the experimentally measured average membrane separations provide a molecular picture of the interplay between glycolipid attraction and steric repulsion of the fluctuating membranes probed in the experiments.
format	article
author	Batuhan Kav Bruno Demé Christian Gege Motomu Tanaka Motomu Tanaka Emanuel Schneck Emanuel Schneck Thomas R. Weikl
author_facet	Batuhan Kav Bruno Demé Christian Gege Motomu Tanaka Motomu Tanaka Emanuel Schneck Emanuel Schneck Thomas R. Weikl
author_sort	Batuhan Kav
title	Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion
title_short	Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion
title_full	Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion
title_fullStr	Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion
title_full_unstemmed	Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion
title_sort	interplay of trans- and cis-interactions of glycolipids in membrane adhesion
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/118ff22e0fd94f2e9f3318ff46a3ac3c
work_keys_str_mv	AT batuhankav interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion AT brunodeme interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion AT christiangege interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion AT motomutanaka interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion AT motomutanaka interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion AT emanuelschneck interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion AT emanuelschneck interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion AT thomasrweikl interplayoftransandcisinteractionsofglycolipidsinmembraneadhesion
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Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion

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