Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer

Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvio...

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Autores principales:	Chak-Shing Kwan, Watson K.-W. Ho, Yanyan Chen, Zongwei Cai, Ken Cham-Fai Leung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	crown ether fibroblast functional dendron macromolecular machine rotaxane dendrimer Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/1190e6c6277c47cfbc71634dd4a1468a
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spelling	oai:doaj.org-article:1190e6c6277c47cfbc71634dd4a1468a2021-11-25T18:48:12ZSynthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer10.3390/polym132239092073-4360https://doaj.org/article/1190e6c6277c47cfbc71634dd4a1468a2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3909https://doaj.org/toc/2073-4360Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 μM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.Chak-Shing KwanWatson K.-W. HoYanyan ChenZongwei CaiKen Cham-Fai LeungMDPI AGarticlecrown etherfibroblastfunctional dendronmacromolecular machinerotaxane dendrimerOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3909, p 3909 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	crown ether fibroblast functional dendron macromolecular machine rotaxane dendrimer Organic chemistry QD241-441
spellingShingle	crown ether fibroblast functional dendron macromolecular machine rotaxane dendrimer Organic chemistry QD241-441 Chak-Shing Kwan Watson K.-W. Ho Yanyan Chen Zongwei Cai Ken Cham-Fai Leung Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer
description	Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 μM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.
format	article
author	Chak-Shing Kwan Watson K.-W. Ho Yanyan Chen Zongwei Cai Ken Cham-Fai Leung
author_facet	Chak-Shing Kwan Watson K.-W. Ho Yanyan Chen Zongwei Cai Ken Cham-Fai Leung
author_sort	Chak-Shing Kwan
title	Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer
title_short	Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer
title_full	Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer
title_fullStr	Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer
title_full_unstemmed	Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer
title_sort	synthesis of functional building blocks for type iii-b rotaxane dendrimer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1190e6c6277c47cfbc71634dd4a1468a
work_keys_str_mv	AT chakshingkwan synthesisoffunctionalbuildingblocksfortypeiiibrotaxanedendrimer AT watsonkwho synthesisoffunctionalbuildingblocksfortypeiiibrotaxanedendrimer AT yanyanchen synthesisoffunctionalbuildingblocksfortypeiiibrotaxanedendrimer AT zongweicai synthesisoffunctionalbuildingblocksfortypeiiibrotaxanedendrimer AT kenchamfaileung synthesisoffunctionalbuildingblocksfortypeiiibrotaxanedendrimer
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Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer

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