The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats

Carvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperal...

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Autores principales:	Milovanović Mirjana, Milosavljević Miloš, Đorđe Marjanović S, Trailović M Saša, Vučinić Marijana, Nedeljković Trailović Jelena, Marković Maja, Đurđević Dragan
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	carvacrol indomethacin nociception motor coordination rat Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/1191ba5b236b4f48ba96a699703d99ad
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spelling	oai:doaj.org-article:1191ba5b236b4f48ba96a699703d99ad2021-11-17T21:27:51ZThe Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats1820-744810.1515/acve-2016-0041https://doaj.org/article/1191ba5b236b4f48ba96a699703d99ad2016-12-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0041https://doaj.org/toc/1820-7448Carvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperalgesia was induced by formalin (1.5%), which was administered SC in the upper lip of rat. Hyperalgesia and effects of carvacrol and indomethacin were measured by using the orofacial formalin test. The influence on motor coordination in animals treated with carvacrol was investigated by using the rota-rod test. Carvacrol administered PO in pre-treatment (45 min. prior to formalin) at a single dose of 50, 75 and 100 mg /kg BW, in the male, 50 and 100 mg /kg BW, in female rats caused a dose-dependent antinociceptive effect. This effect of carvacrol was significantly higher (P<0.01, P<0.001) in male rats. Compared with indomethacin administered during pre-treatment (2 mg/kg, PO), carvacrol (100 mg/kg) exhibits significantly higher (P <0.05 and P <0.001) antinociceptive effect on formalininduced hyperalgesia in male rats. In the rota-rod test carvacrol did not disturb the motor coordination in male rats, nor the dose of carvacrol with clear antinociceptive properties exhibited depressive effect on the CNS of treated rats. Keeping in mind that the monoterpene carvacrol is of plant origin, with potentially less side effects and without residues, it is realistic to expect the possibility of its therapeutic use in the treatment of inflammatory pain in animals.Milovanović MirjanaMilosavljević MilošĐorđe Marjanović STrailović M SašaVučinić MarijanaNedeljković Trailović JelenaMarković MajaĐurđević DraganSciendoarticlecarvacrolindomethacinnociceptionmotor coordinationratVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 4, Pp 478-488 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	carvacrol indomethacin nociception motor coordination rat Veterinary medicine SF600-1100
spellingShingle	carvacrol indomethacin nociception motor coordination rat Veterinary medicine SF600-1100 Milovanović Mirjana Milosavljević Miloš Đorđe Marjanović S Trailović M Saša Vučinić Marijana Nedeljković Trailović Jelena Marković Maja Đurđević Dragan The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats
description	Carvacrol is a monoterpenic phenol and an active ingredient of the plant essential oils of the family Lamiaceae. We have investigated the analgesic effect of carvacrol, the possible dependence of the effect in relation to animal sex, and the impact of carvacrol on motor coordination in rats. Hyperalgesia was induced by formalin (1.5%), which was administered SC in the upper lip of rat. Hyperalgesia and effects of carvacrol and indomethacin were measured by using the orofacial formalin test. The influence on motor coordination in animals treated with carvacrol was investigated by using the rota-rod test. Carvacrol administered PO in pre-treatment (45 min. prior to formalin) at a single dose of 50, 75 and 100 mg /kg BW, in the male, 50 and 100 mg /kg BW, in female rats caused a dose-dependent antinociceptive effect. This effect of carvacrol was significantly higher (P<0.01, P<0.001) in male rats. Compared with indomethacin administered during pre-treatment (2 mg/kg, PO), carvacrol (100 mg/kg) exhibits significantly higher (P <0.05 and P <0.001) antinociceptive effect on formalininduced hyperalgesia in male rats. In the rota-rod test carvacrol did not disturb the motor coordination in male rats, nor the dose of carvacrol with clear antinociceptive properties exhibited depressive effect on the CNS of treated rats. Keeping in mind that the monoterpene carvacrol is of plant origin, with potentially less side effects and without residues, it is realistic to expect the possibility of its therapeutic use in the treatment of inflammatory pain in animals.
format	article
author	Milovanović Mirjana Milosavljević Miloš Đorđe Marjanović S Trailović M Saša Vučinić Marijana Nedeljković Trailović Jelena Marković Maja Đurđević Dragan
author_facet	Milovanović Mirjana Milosavljević Miloš Đorđe Marjanović S Trailović M Saša Vučinić Marijana Nedeljković Trailović Jelena Marković Maja Đurđević Dragan
author_sort	Milovanović Mirjana
title	The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats
title_short	The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats
title_full	The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats
title_fullStr	The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats
title_full_unstemmed	The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats
title_sort	effect of carvacrol on inflammatory pain and motor coordination in rats
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/1191ba5b236b4f48ba96a699703d99ad
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The Effect of Carvacrol on Inflammatory Pain and Motor Coordination in Rats

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