Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank

Abstract APOE genotypes are associated with ischemic heart disease (IHD), several other cardiovascular diseases and dementia. Previous studies have not comprehensively considered all genotypes, especially ε2ε2, nor associations by age and sex, although IHD incidence differs by sex. In the UK Biobank...

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Autores principales:	Mengyu Li, Jie V. Zhao, Man Ki Kwok, C. Mary Schooling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1192fbf6dcb14711bc24b5413ca8e03b
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spelling	oai:doaj.org-article:1192fbf6dcb14711bc24b5413ca8e03b2021-12-02T16:56:10ZAge and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank10.1038/s41598-021-88256-x2045-2322https://doaj.org/article/1192fbf6dcb14711bc24b5413ca8e03b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88256-xhttps://doaj.org/toc/2045-2322Abstract APOE genotypes are associated with ischemic heart disease (IHD), several other cardiovascular diseases and dementia. Previous studies have not comprehensively considered all genotypes, especially ε2ε2, nor associations by age and sex, although IHD incidence differs by sex. In the UK Biobank, including 391,992 white British participants, we compared effects of APOE genotypes on IHD and its risk factors. Compared to the ε3ε3 genotype, ε2ε2 was not clearly associated with IHD but was associated with lower plasma apolipoprotein B (apoB). The ε2ε3 genotype conferred lower IHD risk, systolic blood pressure (SBP), pulse pressure and plasma apoB than ε3ε3. ε3ε4 and ε4ε4 conferred higher IHD risk, higher pulse pressure and plasma apoB, but lower glycated haemoglobin (HbA1c) than ε3ε3. The associations by age and sex were fairly similar, except ε2ε2 compared to ε3ε3 was marginally positively associated with IHD in the younger age group and nominally inversely associated with SBP in men. ε3ε4 compared to ε3ε3 was nominally positively associated with SBP in women. APOE genotypes affect IHD risk increasingly from ε2ε3, ε3ε3, ε3ε4 to ε4ε4, with similar patterns for pulse pressure and plasma apoB, but not for diabetes. Associations with blood pressure differed by sex. Greater understanding of products of APOE and their effects might generate targets of intervention.Mengyu LiJie V. ZhaoMan Ki KwokC. Mary SchoolingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengyu Li Jie V. Zhao Man Ki Kwok C. Mary Schooling Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank
description	Abstract APOE genotypes are associated with ischemic heart disease (IHD), several other cardiovascular diseases and dementia. Previous studies have not comprehensively considered all genotypes, especially ε2ε2, nor associations by age and sex, although IHD incidence differs by sex. In the UK Biobank, including 391,992 white British participants, we compared effects of APOE genotypes on IHD and its risk factors. Compared to the ε3ε3 genotype, ε2ε2 was not clearly associated with IHD but was associated with lower plasma apolipoprotein B (apoB). The ε2ε3 genotype conferred lower IHD risk, systolic blood pressure (SBP), pulse pressure and plasma apoB than ε3ε3. ε3ε4 and ε4ε4 conferred higher IHD risk, higher pulse pressure and plasma apoB, but lower glycated haemoglobin (HbA1c) than ε3ε3. The associations by age and sex were fairly similar, except ε2ε2 compared to ε3ε3 was marginally positively associated with IHD in the younger age group and nominally inversely associated with SBP in men. ε3ε4 compared to ε3ε3 was nominally positively associated with SBP in women. APOE genotypes affect IHD risk increasingly from ε2ε3, ε3ε3, ε3ε4 to ε4ε4, with similar patterns for pulse pressure and plasma apoB, but not for diabetes. Associations with blood pressure differed by sex. Greater understanding of products of APOE and their effects might generate targets of intervention.
format	article
author	Mengyu Li Jie V. Zhao Man Ki Kwok C. Mary Schooling
author_facet	Mengyu Li Jie V. Zhao Man Ki Kwok C. Mary Schooling
author_sort	Mengyu Li
title	Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank
title_short	Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank
title_full	Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank
title_fullStr	Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank
title_full_unstemmed	Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank
title_sort	age and sex specific effects of apoe genotypes on ischemic heart disease and its risk factors in the uk biobank
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1192fbf6dcb14711bc24b5413ca8e03b
work_keys_str_mv	AT mengyuli ageandsexspecificeffectsofapoegenotypesonischemicheartdiseaseanditsriskfactorsintheukbiobank AT jievzhao ageandsexspecificeffectsofapoegenotypesonischemicheartdiseaseanditsriskfactorsintheukbiobank AT mankikwok ageandsexspecificeffectsofapoegenotypesonischemicheartdiseaseanditsriskfactorsintheukbiobank AT cmaryschooling ageandsexspecificeffectsofapoegenotypesonischemicheartdiseaseanditsriskfactorsintheukbiobank
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Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank

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