Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants

The role played by human protein TLR2 in inflammation and sepsis varies for different bacterial pathogens. Here, Hanzelmann et al. show that the differential abilities of Staphylococcus aureusstrains to activate TLR2 depend on their production of peptides that release lipoproteins known to act as TL...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Dennis Hanzelmann, Hwang-Soo Joo, Mirita Franz-Wachtel, Tobias Hertlein, Stefan Stevanovic, Boris Macek, Christiane Wolz, Friedrich Götz, Michael Otto, Dorothee Kretschmer, Andreas Peschel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1193e0fa2ae749c19e681f02dac202f8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1193e0fa2ae749c19e681f02dac202f8
record_format	dspace
spelling	oai:doaj.org-article:1193e0fa2ae749c19e681f02dac202f82021-12-02T14:38:57ZToll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants10.1038/ncomms123042041-1723https://doaj.org/article/1193e0fa2ae749c19e681f02dac202f82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12304https://doaj.org/toc/2041-1723The role played by human protein TLR2 in inflammation and sepsis varies for different bacterial pathogens. Here, Hanzelmann et al. show that the differential abilities of Staphylococcus aureusstrains to activate TLR2 depend on their production of peptides that release lipoproteins known to act as TLR2 agonists.Dennis HanzelmannHwang-Soo JooMirita Franz-WachtelTobias HertleinStefan StevanovicBoris MacekChristiane WolzFriedrich GötzMichael OttoDorothee KretschmerAndreas PeschelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dennis Hanzelmann Hwang-Soo Joo Mirita Franz-Wachtel Tobias Hertlein Stefan Stevanovic Boris Macek Christiane Wolz Friedrich Götz Michael Otto Dorothee Kretschmer Andreas Peschel Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
description	The role played by human protein TLR2 in inflammation and sepsis varies for different bacterial pathogens. Here, Hanzelmann et al. show that the differential abilities of Staphylococcus aureusstrains to activate TLR2 depend on their production of peptides that release lipoproteins known to act as TLR2 agonists.
format	article
author	Dennis Hanzelmann Hwang-Soo Joo Mirita Franz-Wachtel Tobias Hertlein Stefan Stevanovic Boris Macek Christiane Wolz Friedrich Götz Michael Otto Dorothee Kretschmer Andreas Peschel
author_facet	Dennis Hanzelmann Hwang-Soo Joo Mirita Franz-Wachtel Tobias Hertlein Stefan Stevanovic Boris Macek Christiane Wolz Friedrich Götz Michael Otto Dorothee Kretschmer Andreas Peschel
author_sort	Dennis Hanzelmann
title	Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
title_short	Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
title_full	Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
title_fullStr	Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
title_full_unstemmed	Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
title_sort	toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1193e0fa2ae749c19e681f02dac202f8
work_keys_str_mv	AT dennishanzelmann tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT hwangsoojoo tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT miritafranzwachtel tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT tobiashertlein tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT stefanstevanovic tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT borismacek tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT christianewolz tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT friedrichgotz tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT michaelotto tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT dorotheekretschmer tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants AT andreaspeschel tolllikereceptor2activationdependsonlipopeptidesheddingbybacterialsurfactants
_version_	1718390755805888512

Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants

Ejemplares similares