Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

ORAI3 is part of pore forming calcium channels involved in T cell activation. Here the authors show that there is increased expression of ORAI3 in T cells from patients with rheumatoid arthritis and that the transcription factor IKAROS negatively regulates the ORAI3 promoter, indicating a regulatory...

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Autores principales:	Zhongde Ye, Yi Shen, Ke Jin, Jingtao Qiu, Bin Hu, Rohit R. Jadhav, Khushboo Sheth, Cornelia M. Weyand, Jörg J. Goronzy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1194013638654e75b64350cd53e610e5
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spelling	oai:doaj.org-article:1194013638654e75b64350cd53e610e52021-12-02T13:30:07ZArachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation10.1038/s41467-021-21242-z2041-1723https://doaj.org/article/1194013638654e75b64350cd53e610e52021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21242-zhttps://doaj.org/toc/2041-1723ORAI3 is part of pore forming calcium channels involved in T cell activation. Here the authors show that there is increased expression of ORAI3 in T cells from patients with rheumatoid arthritis and that the transcription factor IKAROS negatively regulates the ORAI3 promoter, indicating a regulatory loop that can control auto-reactivity of T cells in these patients.Zhongde YeYi ShenKe JinJingtao QiuBin HuRohit R. JadhavKhushboo ShethCornelia M. WeyandJörg J. GoronzyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhongde Ye Yi Shen Ke Jin Jingtao Qiu Bin Hu Rohit R. Jadhav Khushboo Sheth Cornelia M. Weyand Jörg J. Goronzy Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation
description	ORAI3 is part of pore forming calcium channels involved in T cell activation. Here the authors show that there is increased expression of ORAI3 in T cells from patients with rheumatoid arthritis and that the transcription factor IKAROS negatively regulates the ORAI3 promoter, indicating a regulatory loop that can control auto-reactivity of T cells in these patients.
format	article
author	Zhongde Ye Yi Shen Ke Jin Jingtao Qiu Bin Hu Rohit R. Jadhav Khushboo Sheth Cornelia M. Weyand Jörg J. Goronzy
author_facet	Zhongde Ye Yi Shen Ke Jin Jingtao Qiu Bin Hu Rohit R. Jadhav Khushboo Sheth Cornelia M. Weyand Jörg J. Goronzy
author_sort	Zhongde Ye
title	Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation
title_short	Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation
title_full	Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation
title_fullStr	Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation
title_full_unstemmed	Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation
title_sort	arachidonic acid-regulated calcium signaling in t cells from patients with rheumatoid arthritis promotes synovial inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1194013638654e75b64350cd53e610e5
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Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

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