Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers

Mass spectrometry is widely used for large-scale lipid profiling but distinguishing unsaturated lipid isomers is still challenging. Here, the authors present an analytical platform for high-throughput identification of lipid C=C location isomers in clinical samples, showing that isomer ratios may gu...

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Autores principales:	Wenpeng Zhang, Donghui Zhang, Qinhua Chen, Junhan Wu, Zheng Ouyang, Yu Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/119768cc75fc467688bcc0bb37a4c0c0
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spelling	oai:doaj.org-article:119768cc75fc467688bcc0bb37a4c0c02021-12-02T16:51:02ZOnline photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers10.1038/s41467-018-07963-82041-1723https://doaj.org/article/119768cc75fc467688bcc0bb37a4c0c02019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07963-8https://doaj.org/toc/2041-1723Mass spectrometry is widely used for large-scale lipid profiling but distinguishing unsaturated lipid isomers is still challenging. Here, the authors present an analytical platform for high-throughput identification of lipid C=C location isomers in clinical samples, showing that isomer ratios may guide biomarker discovery.Wenpeng ZhangDonghui ZhangQinhua ChenJunhan WuZheng OuyangYu XiaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenpeng Zhang Donghui Zhang Qinhua Chen Junhan Wu Zheng Ouyang Yu Xia Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers
description	Mass spectrometry is widely used for large-scale lipid profiling but distinguishing unsaturated lipid isomers is still challenging. Here, the authors present an analytical platform for high-throughput identification of lipid C=C location isomers in clinical samples, showing that isomer ratios may guide biomarker discovery.
format	article
author	Wenpeng Zhang Donghui Zhang Qinhua Chen Junhan Wu Zheng Ouyang Yu Xia
author_facet	Wenpeng Zhang Donghui Zhang Qinhua Chen Junhan Wu Zheng Ouyang Yu Xia
author_sort	Wenpeng Zhang
title	Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers
title_short	Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers
title_full	Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers
title_fullStr	Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers
title_full_unstemmed	Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers
title_sort	online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/119768cc75fc467688bcc0bb37a4c0c0
work_keys_str_mv	AT wenpengzhang onlinephotochemicalderivatizationenablescomprehensivemassspectrometricanalysisofunsaturatedphospholipidisomers AT donghuizhang onlinephotochemicalderivatizationenablescomprehensivemassspectrometricanalysisofunsaturatedphospholipidisomers AT qinhuachen onlinephotochemicalderivatizationenablescomprehensivemassspectrometricanalysisofunsaturatedphospholipidisomers AT junhanwu onlinephotochemicalderivatizationenablescomprehensivemassspectrometricanalysisofunsaturatedphospholipidisomers AT zhengouyang onlinephotochemicalderivatizationenablescomprehensivemassspectrometricanalysisofunsaturatedphospholipidisomers AT yuxia onlinephotochemicalderivatizationenablescomprehensivemassspectrometricanalysisofunsaturatedphospholipidisomers
_version_	1718382962280497152

Online photochemical derivatization enables comprehensive mass spectrometric analysis of unsaturated phospholipid isomers

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