Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor recruitment near affected splice junctions.

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Autores principales:	Justin J. -L. Wong, Dadi Gao, Trung V. Nguyen, Chau-To Kwok, Michelle van Geldermalsen, Rob Middleton, Natalia Pinello, Annora Thoeng, Rajini Nagarajah, Jeff Holst, William Ritchie, John E. J. Rasko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/119a506ca1a641cd82f6def9763f7671
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spelling	oai:doaj.org-article:119a506ca1a641cd82f6def9763f76712021-12-02T17:06:04ZIntron retention is regulated by altered MeCP2-mediated splicing factor recruitment10.1038/ncomms151342041-1723https://doaj.org/article/119a506ca1a641cd82f6def9763f76712017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15134https://doaj.org/toc/2041-1723Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor recruitment near affected splice junctions.Justin J. -L. WongDadi GaoTrung V. NguyenChau-To KwokMichelle van GeldermalsenRob MiddletonNatalia PinelloAnnora ThoengRajini NagarajahJeff HolstWilliam RitchieJohn E. J. RaskoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Justin J. -L. Wong Dadi Gao Trung V. Nguyen Chau-To Kwok Michelle van Geldermalsen Rob Middleton Natalia Pinello Annora Thoeng Rajini Nagarajah Jeff Holst William Ritchie John E. J. Rasko Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
description	Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor recruitment near affected splice junctions.
format	article
author	Justin J. -L. Wong Dadi Gao Trung V. Nguyen Chau-To Kwok Michelle van Geldermalsen Rob Middleton Natalia Pinello Annora Thoeng Rajini Nagarajah Jeff Holst William Ritchie John E. J. Rasko
author_facet	Justin J. -L. Wong Dadi Gao Trung V. Nguyen Chau-To Kwok Michelle van Geldermalsen Rob Middleton Natalia Pinello Annora Thoeng Rajini Nagarajah Jeff Holst William Ritchie John E. J. Rasko
author_sort	Justin J. -L. Wong
title	Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
title_short	Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
title_full	Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
title_fullStr	Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
title_full_unstemmed	Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
title_sort	intron retention is regulated by altered mecp2-mediated splicing factor recruitment
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/119a506ca1a641cd82f6def9763f7671
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Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

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