Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment

Intron retention is a conserved mechanism that controls gene expression but its regulation is poorly understood. Here, the authors provide evidence that DNA methylation regulates intron retention and find reduced MeCP2 occupancy and splicing factor recruitment near affected splice junctions.

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Detalles Bibliográficos
Autores principales: Justin J. -L. Wong, Dadi Gao, Trung V. Nguyen, Chau-To Kwok, Michelle van Geldermalsen, Rob Middleton, Natalia Pinello, Annora Thoeng, Rajini Nagarajah, Jeff Holst, William Ritchie, John E. J. Rasko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/119a506ca1a641cd82f6def9763f7671
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Internet

https://doaj.org/article/119a506ca1a641cd82f6def9763f7671

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