Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.

<h4>Background</h4>Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. Macrophage receptor with a collagenous structure (MARCO) is essential components required for toll like receptor-signaling in m...

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Autores principales:	Mai-Juan Ma, Hai-Bing Wang, Hao Li, Jun-Hai Yang, Yan Yan, Lan-Pin Xie, Ying-Cheng Qi, Jun-Lian Li, Mei-Juan Chen, Wei Liu, Wu-Chun Cao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/119ae5ffc81c469a8cf47c3c957f7dcd
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spelling	oai:doaj.org-article:119ae5ffc81c469a8cf47c3c957f7dcd2021-11-18T06:47:26ZGenetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.1932-620310.1371/journal.pone.0024069https://doaj.org/article/119ae5ffc81c469a8cf47c3c957f7dcd2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21886847/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. Macrophage receptor with a collagenous structure (MARCO) is essential components required for toll like receptor-signaling in macrophage response to Mycobacterium tuberculosis, which may contribute to tuberculosis risk.<h4>Principal findings</h4>To specifically investigated whether single nucleotide polymorphisms (SNPs) in MARCO gene are associated with pulmonary tuberculosis in Chinese Han population. By selecting tagging SNPs in MARCO gene, 17 tag SNPs were identified and genotyped in 923 pulmonary tuberculosis patients and 1033 healthy control subjects using a hospital based case-control association study. Single-point and haplotype analysis revealed an association in intron and exon region of MARCO gene. One SNP (rs17009726) was associated with susceptibility to pulmonary tuberculosis, where the carriers of the G allele had a 1.65 fold (95% CI = 1.32-2.05, p(corrected) = 9.27E-5) increased risk of pulmonary tuberculosis. Haplotype analysis revealed that haplotype GC containing G allele of 17009726 and haplotype TGCC (rs17795618T/A, rs1371562G/T, rs6761637T/C, rs2011839C/T) were also associated with susceptibility to pulmonary tuberculosis (p(corrected) = 0.0001 and 0.029, respectively).<h4>Conclusions</h4>Our study suggested that genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population, and the findings emphasize the importance of MARCO mediated immune responses in the pathogenesis of tuberculosis.Mai-Juan MaHai-Bing WangHao LiJun-Hai YangYan YanLan-Pin XieYing-Cheng QiJun-Lian LiMei-Juan ChenWei LiuWu-Chun CaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e24069 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mai-Juan Ma Hai-Bing Wang Hao Li Jun-Hai Yang Yan Yan Lan-Pin Xie Ying-Cheng Qi Jun-Lian Li Mei-Juan Chen Wei Liu Wu-Chun Cao Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
description	<h4>Background</h4>Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. Macrophage receptor with a collagenous structure (MARCO) is essential components required for toll like receptor-signaling in macrophage response to Mycobacterium tuberculosis, which may contribute to tuberculosis risk.<h4>Principal findings</h4>To specifically investigated whether single nucleotide polymorphisms (SNPs) in MARCO gene are associated with pulmonary tuberculosis in Chinese Han population. By selecting tagging SNPs in MARCO gene, 17 tag SNPs were identified and genotyped in 923 pulmonary tuberculosis patients and 1033 healthy control subjects using a hospital based case-control association study. Single-point and haplotype analysis revealed an association in intron and exon region of MARCO gene. One SNP (rs17009726) was associated with susceptibility to pulmonary tuberculosis, where the carriers of the G allele had a 1.65 fold (95% CI = 1.32-2.05, p(corrected) = 9.27E-5) increased risk of pulmonary tuberculosis. Haplotype analysis revealed that haplotype GC containing G allele of 17009726 and haplotype TGCC (rs17795618T/A, rs1371562G/T, rs6761637T/C, rs2011839C/T) were also associated with susceptibility to pulmonary tuberculosis (p(corrected) = 0.0001 and 0.029, respectively).<h4>Conclusions</h4>Our study suggested that genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population, and the findings emphasize the importance of MARCO mediated immune responses in the pathogenesis of tuberculosis.
format	article
author	Mai-Juan Ma Hai-Bing Wang Hao Li Jun-Hai Yang Yan Yan Lan-Pin Xie Ying-Cheng Qi Jun-Lian Li Mei-Juan Chen Wei Liu Wu-Chun Cao
author_facet	Mai-Juan Ma Hai-Bing Wang Hao Li Jun-Hai Yang Yan Yan Lan-Pin Xie Ying-Cheng Qi Jun-Lian Li Mei-Juan Chen Wei Liu Wu-Chun Cao
author_sort	Mai-Juan Ma
title	Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
title_short	Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
title_full	Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
title_fullStr	Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
title_full_unstemmed	Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.
title_sort	genetic variants in marco are associated with the susceptibility to pulmonary tuberculosis in chinese han population.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/119ae5ffc81c469a8cf47c3c957f7dcd
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Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population.

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