Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study

Abstract Prior cross-sectional analyses have demonstrated an association between subclinical hypothyroidism and metabolic syndrome and selected components. However, the temporal relation between metabolic syndrome and declining thyroid function remains unclear. In a prospective study, an unselected...

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Autores principales:	Chia-Hsuin Chang, Yi-Chun Yeh, James L. Caffrey, Shyang-Rong Shih, Lee-Ming Chuang, Yu-Kang Tu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/119b1084133b4bbea19afd60fbad40e1
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spelling	oai:doaj.org-article:119b1084133b4bbea19afd60fbad40e12021-12-02T15:06:27ZMetabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study10.1038/s41598-017-07004-22045-2322https://doaj.org/article/119b1084133b4bbea19afd60fbad40e12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07004-2https://doaj.org/toc/2045-2322Abstract Prior cross-sectional analyses have demonstrated an association between subclinical hypothyroidism and metabolic syndrome and selected components. However, the temporal relation between metabolic syndrome and declining thyroid function remains unclear. In a prospective study, an unselected cohort of 66,822 participants with and without metabolic syndrome were followed. A proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% CIs for hypothyroidism. Exploratory analyses for the relation between components of metabolic syndrome and declining thyroid function were also undertaken. During an average follow-up of 4.2 years, the incident rates for subclinical hypothyroidism were substantially higher in participants who began the study with metabolic syndrome compared with metabolically normal controls. After controlling for risk factors, patients with metabolic syndrome were at a 21% excess risk of developing subclinical hypothyroidism (adjusted HR 1.21; 95% CI 1.03–1.42). When individual components were analyzed, an increased risk of subclinical hypothyroidism was associated with high blood pressure (1.24; 1.04–1.48) and high serum triglycerides (1.18; 1.00–1.39), with a trend of increasing risk as participants had additional more components. Individuals with metabolic syndrome are at a greater risk for developing subclinical hypothyroidism, while its mechanisms and temporal consequences of this observation remain to be determined.Chia-Hsuin ChangYi-Chun YehJames L. CaffreyShyang-Rong ShihLee-Ming ChuangYu-Kang TuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Hsuin Chang Yi-Chun Yeh James L. Caffrey Shyang-Rong Shih Lee-Ming Chuang Yu-Kang Tu Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study
description	Abstract Prior cross-sectional analyses have demonstrated an association between subclinical hypothyroidism and metabolic syndrome and selected components. However, the temporal relation between metabolic syndrome and declining thyroid function remains unclear. In a prospective study, an unselected cohort of 66,822 participants with and without metabolic syndrome were followed. A proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% CIs for hypothyroidism. Exploratory analyses for the relation between components of metabolic syndrome and declining thyroid function were also undertaken. During an average follow-up of 4.2 years, the incident rates for subclinical hypothyroidism were substantially higher in participants who began the study with metabolic syndrome compared with metabolically normal controls. After controlling for risk factors, patients with metabolic syndrome were at a 21% excess risk of developing subclinical hypothyroidism (adjusted HR 1.21; 95% CI 1.03–1.42). When individual components were analyzed, an increased risk of subclinical hypothyroidism was associated with high blood pressure (1.24; 1.04–1.48) and high serum triglycerides (1.18; 1.00–1.39), with a trend of increasing risk as participants had additional more components. Individuals with metabolic syndrome are at a greater risk for developing subclinical hypothyroidism, while its mechanisms and temporal consequences of this observation remain to be determined.
format	article
author	Chia-Hsuin Chang Yi-Chun Yeh James L. Caffrey Shyang-Rong Shih Lee-Ming Chuang Yu-Kang Tu
author_facet	Chia-Hsuin Chang Yi-Chun Yeh James L. Caffrey Shyang-Rong Shih Lee-Ming Chuang Yu-Kang Tu
author_sort	Chia-Hsuin Chang
title	Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study
title_short	Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study
title_full	Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study
title_fullStr	Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study
title_full_unstemmed	Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study
title_sort	metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – a cohort study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/119b1084133b4bbea19afd60fbad40e1
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Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism – A Cohort Study

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