Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China

Atrial fibrillation (AF) is an important cardiovascular disease that causes a great burden of disease. However, there is limited evidence of a link between air pollution exposure and AF. This study aimed to explore the short-term association between air pollution and AF. We obtained daily hospitaliz...

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Autores principales:	Yan Fang, Hongyi Cheng, Xu Li, Yifan Xu, Hang Xu, Zhichao Chen, Weixin Cai, Cong Liu, Jingyan Cao
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Air pollution Criteria air pollutants Atrial fibrillation Time-series study Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/11a11b67d31e463996167c3b5db54dc1
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spelling	oai:doaj.org-article:11a11b67d31e463996167c3b5db54dc12021-11-12T04:24:03ZShort-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China0147-651310.1016/j.ecoenv.2021.112961https://doaj.org/article/11a11b67d31e463996167c3b5db54dc12021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010733https://doaj.org/toc/0147-6513Atrial fibrillation (AF) is an important cardiovascular disease that causes a great burden of disease. However, there is limited evidence of a link between air pollution exposure and AF. This study aimed to explore the short-term association between air pollution and AF. We obtained daily hospitalization of AF in two major hospitals of Yancheng, China from May, 2015 to May, 2020. Generalized additive models with quasi-Poisson regression were used to assess the associations between six criteria air pollutants and AF hospitalization. We explored the lag patterns, and visualized the concentration-response relationships. The robustness of the association was tested by two-pollutant model, and we explored potential effect modification by age, sex and season. A total of 15,171 inpatients from two hospitals were collected in this study with an average daily count of eight patients. We observed consistent and significant associations between six air pollutants and AF on lag 0–4 days. A 10 ug/m3 increase in PM2.5 was associated with 2.81% (95%CI: 1.44%, 4.20%) changes in AF, and the effect estimate was 1.67% (95%CI: 0.77%, 2.59%) for PM10, 4.90% (95%CI: 1.69%, 8.22%) for NO2, 6.81% (95%CI: 0.46%, 13.57%) for SO2, 1.82% (95%CI: 0.60%, 3.06%) for O3; a 0.1 mg/m3 increase in CO was associated with 2.55% (95%CI: 0.91%, 4.21%) increments in AF. Associations of PM2.5 and PM10 were robust after adjusting for SO2, NO2, CO, and O3, but not vice versa. Female patients and those aged less 70 years had larger risk of AF associated with air pollution exposure. The concentration-response curves of the six pollutants were almost linear and increasing with no obvious thresholds. This time-series study in Yancheng demonstrated increased risk of AF and a delayed effect over lag 0–4 days. Our findings suggested need of prevention and protection against these environmental risk factors for AF in health departments.Yan FangHongyi ChengXu LiYifan XuHang XuZhichao ChenWeixin CaiCong LiuJingyan CaoElsevierarticleAir pollutionCriteria air pollutantsAtrial fibrillationTime-series studyEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 112961- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Air pollution Criteria air pollutants Atrial fibrillation Time-series study Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Air pollution Criteria air pollutants Atrial fibrillation Time-series study Environmental pollution TD172-193.5 Environmental sciences GE1-350 Yan Fang Hongyi Cheng Xu Li Yifan Xu Hang Xu Zhichao Chen Weixin Cai Cong Liu Jingyan Cao Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China
description	Atrial fibrillation (AF) is an important cardiovascular disease that causes a great burden of disease. However, there is limited evidence of a link between air pollution exposure and AF. This study aimed to explore the short-term association between air pollution and AF. We obtained daily hospitalization of AF in two major hospitals of Yancheng, China from May, 2015 to May, 2020. Generalized additive models with quasi-Poisson regression were used to assess the associations between six criteria air pollutants and AF hospitalization. We explored the lag patterns, and visualized the concentration-response relationships. The robustness of the association was tested by two-pollutant model, and we explored potential effect modification by age, sex and season. A total of 15,171 inpatients from two hospitals were collected in this study with an average daily count of eight patients. We observed consistent and significant associations between six air pollutants and AF on lag 0–4 days. A 10 ug/m3 increase in PM2.5 was associated with 2.81% (95%CI: 1.44%, 4.20%) changes in AF, and the effect estimate was 1.67% (95%CI: 0.77%, 2.59%) for PM10, 4.90% (95%CI: 1.69%, 8.22%) for NO2, 6.81% (95%CI: 0.46%, 13.57%) for SO2, 1.82% (95%CI: 0.60%, 3.06%) for O3; a 0.1 mg/m3 increase in CO was associated with 2.55% (95%CI: 0.91%, 4.21%) increments in AF. Associations of PM2.5 and PM10 were robust after adjusting for SO2, NO2, CO, and O3, but not vice versa. Female patients and those aged less 70 years had larger risk of AF associated with air pollution exposure. The concentration-response curves of the six pollutants were almost linear and increasing with no obvious thresholds. This time-series study in Yancheng demonstrated increased risk of AF and a delayed effect over lag 0–4 days. Our findings suggested need of prevention and protection against these environmental risk factors for AF in health departments.
format	article
author	Yan Fang Hongyi Cheng Xu Li Yifan Xu Hang Xu Zhichao Chen Weixin Cai Cong Liu Jingyan Cao
author_facet	Yan Fang Hongyi Cheng Xu Li Yifan Xu Hang Xu Zhichao Chen Weixin Cai Cong Liu Jingyan Cao
author_sort	Yan Fang
title	Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China
title_short	Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China
title_full	Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China
title_fullStr	Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China
title_full_unstemmed	Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China
title_sort	short-term exposure to ambient air pollution and atrial fibrillation hospitalization: a time-series study in yancheng, china
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/11a11b67d31e463996167c3b5db54dc1
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Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China

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