Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers

Mobile measures of human circadian rhythms (CR) are needed in the age of chronotherapy. Two wearable measures of CR have recently been validated: one that uses heart rate to extract circadian rhythms that originate in the sinoatrial node of the heart, and another that uses activity to predict the la...

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Autores principales:	Yitong Huang, Caleb Mayer, Olivia J. Walch, Clark Bowman, Srijan Sen, Cathy Goldstein, Jonathan Tyler, Daniel B. Forger
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	circadian rhythm wearables internal desynchrony heart rate social distancing Medicine R Public aspects of medicine RA1-1270 Electronic computers. Computer science QA75.5-76.95
Acceso en línea:	https://doaj.org/article/11a45d2cf1784502b330eca81400c15a
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spelling	oai:doaj.org-article:11a45d2cf1784502b330eca81400c15a2021-11-16T04:52:37ZDistinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers2673-253X10.3389/fdgth.2021.727504https://doaj.org/article/11a45d2cf1784502b330eca81400c15a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fdgth.2021.727504/fullhttps://doaj.org/toc/2673-253XMobile measures of human circadian rhythms (CR) are needed in the age of chronotherapy. Two wearable measures of CR have recently been validated: one that uses heart rate to extract circadian rhythms that originate in the sinoatrial node of the heart, and another that uses activity to predict the laboratory gold standard and central circadian pacemaker marker, dim light melatonin onset (DLMO). We first find that the heart rate markers of normal real-world individuals align with laboratory DLMO measurements when we account for heart rate phase error. Next, we expand upon previous work that has examined sleep patterns or chronotypes during the COVID-19 lockdown by studying the effects of social distancing on circadian rhythms. In particular, using data collected from the Social Rhythms app, a mobile application where individuals upload their wearable data and receive reports on their circadian rhythms, we compared the two circadian phase estimates before and after social distancing. Interestingly, we found that the lockdown had different effects on the two ambulatory measurements. Before the lockdown, the two measures aligned, as predicted by laboratory data. After the lockdown, when circadian timekeeping signals were blunted, these measures diverged in 70% of subjects (with circadian rhythms in heart rate, or CRHR, becoming delayed). Thus, while either approach can measure circadian rhythms, both are needed to understand internal desynchrony. We also argue that interventions may be needed in future lockdowns to better align separate circadian rhythms in the body.Yitong HuangCaleb MayerOlivia J. WalchClark BowmanSrijan SenSrijan SenCathy GoldsteinJonathan TylerJonathan TylerDaniel B. ForgerDaniel B. ForgerDaniel B. ForgerFrontiers Media S.A.articlecircadian rhythmwearablesinternal desynchronyheart ratesocial distancingMedicineRPublic aspects of medicineRA1-1270Electronic computers. Computer scienceQA75.5-76.95ENFrontiers in Digital Health, Vol 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circadian rhythm wearables internal desynchrony heart rate social distancing Medicine R Public aspects of medicine RA1-1270 Electronic computers. Computer science QA75.5-76.95
spellingShingle	circadian rhythm wearables internal desynchrony heart rate social distancing Medicine R Public aspects of medicine RA1-1270 Electronic computers. Computer science QA75.5-76.95 Yitong Huang Caleb Mayer Olivia J. Walch Clark Bowman Srijan Sen Srijan Sen Cathy Goldstein Jonathan Tyler Jonathan Tyler Daniel B. Forger Daniel B. Forger Daniel B. Forger Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
description	Mobile measures of human circadian rhythms (CR) are needed in the age of chronotherapy. Two wearable measures of CR have recently been validated: one that uses heart rate to extract circadian rhythms that originate in the sinoatrial node of the heart, and another that uses activity to predict the laboratory gold standard and central circadian pacemaker marker, dim light melatonin onset (DLMO). We first find that the heart rate markers of normal real-world individuals align with laboratory DLMO measurements when we account for heart rate phase error. Next, we expand upon previous work that has examined sleep patterns or chronotypes during the COVID-19 lockdown by studying the effects of social distancing on circadian rhythms. In particular, using data collected from the Social Rhythms app, a mobile application where individuals upload their wearable data and receive reports on their circadian rhythms, we compared the two circadian phase estimates before and after social distancing. Interestingly, we found that the lockdown had different effects on the two ambulatory measurements. Before the lockdown, the two measures aligned, as predicted by laboratory data. After the lockdown, when circadian timekeeping signals were blunted, these measures diverged in 70% of subjects (with circadian rhythms in heart rate, or CRHR, becoming delayed). Thus, while either approach can measure circadian rhythms, both are needed to understand internal desynchrony. We also argue that interventions may be needed in future lockdowns to better align separate circadian rhythms in the body.
format	article
author	Yitong Huang Caleb Mayer Olivia J. Walch Clark Bowman Srijan Sen Srijan Sen Cathy Goldstein Jonathan Tyler Jonathan Tyler Daniel B. Forger Daniel B. Forger Daniel B. Forger
author_facet	Yitong Huang Caleb Mayer Olivia J. Walch Clark Bowman Srijan Sen Srijan Sen Cathy Goldstein Jonathan Tyler Jonathan Tyler Daniel B. Forger Daniel B. Forger Daniel B. Forger
author_sort	Yitong Huang
title	Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
title_short	Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
title_full	Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
title_fullStr	Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
title_full_unstemmed	Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers
title_sort	distinct circadian assessments from wearable data reveal social distancing promoted internal desynchrony between circadian markers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/11a45d2cf1784502b330eca81400c15a
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Distinct Circadian Assessments From Wearable Data Reveal Social Distancing Promoted Internal Desynchrony Between Circadian Markers

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