Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies

During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies) during the wake–sleep cycle. Neural oscillations are electrobiomarkers of the connectivity state within syste...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lahogue Caroline, Pinault Didier
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	delta oscillations gamma oscillations nmda receptors non-rem sleep psychosis transition quantitative eeg pentobarbital spindles thalamus transcranial electrical stimulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/11a4823102a4451ab759654be97623bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:11a4823102a4451ab759654be97623bc
record_format	dspace
spelling	oai:doaj.org-article:11a4823102a4451ab759654be97623bc2021-12-05T14:11:05ZFrontoparietal anodal tDCS reduces ketamine-induced oscillopathies2081-693610.1515/tnsci-2020-0157https://doaj.org/article/11a4823102a4451ab759654be97623bc2021-06-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0157https://doaj.org/toc/2081-6936During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies) during the wake–sleep cycle. Neural oscillations are electrobiomarkers of the connectivity state within systems. A single-systemic administration of ketamine, a non-competitive NMDA glutamate receptor antagonist, transiently reproduces the oscillopathies with a clinical picture reminiscent of the psychosis prodrome. This acute pharmacological model may help the research and development of innovative treatments against psychotic transition. Transcranial electrical stimulation is recognized as an appropriate non-invasive therapeutic modality since it can increase cognitive performance and modulate neural oscillations with little or no side effects. Therefore, our objective was to set up, in the sedated adult rat, a stimulation method that is able to normalize ketamine-induced increase in gamma-frequency (30–80 Hz) oscillations and decrease in sigma-frequency (10–17 Hz) oscillations. Unilateral and bipolar frontoparietal (FP), transcranial anodal stimulation by direct current (<+1 mA) was applied in ketamine-treated rats. A concomitant bilateral electroencephalographic recording of the parietal cortex measured the stimulation effects on its spontaneously occurring oscillations. A 5 min FP anodal tDCS immediately and quickly reduced, significantly with an intensity-effect relationship, the ketamine-induced gamma hyperactivity, and sigma hypoactivity at least in the bilateral parietal cortex. A duration effect was also recorded. The tDCS also tended to diminish the ketamine-induced delta hypoactivity. These preliminary neurophysiological findings are promising for developing a therapeutic proof-of-concept against neuropsychiatric disorders.Lahogue CarolinePinault DidierDe Gruyterarticledelta oscillationsgamma oscillationsnmda receptorsnon-rem sleeppsychosis transitionquantitative eegpentobarbitalspindlesthalamustranscranial electrical stimulationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 282-296 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	delta oscillations gamma oscillations nmda receptors non-rem sleep psychosis transition quantitative eeg pentobarbital spindles thalamus transcranial electrical stimulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	delta oscillations gamma oscillations nmda receptors non-rem sleep psychosis transition quantitative eeg pentobarbital spindles thalamus transcranial electrical stimulation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Lahogue Caroline Pinault Didier Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
description	During the prodromal phase of schizophrenia with its complex and insidious clinical picture, electroencephalographic recordings detect widespread oscillation disturbances (or oscillopathies) during the wake–sleep cycle. Neural oscillations are electrobiomarkers of the connectivity state within systems. A single-systemic administration of ketamine, a non-competitive NMDA glutamate receptor antagonist, transiently reproduces the oscillopathies with a clinical picture reminiscent of the psychosis prodrome. This acute pharmacological model may help the research and development of innovative treatments against psychotic transition. Transcranial electrical stimulation is recognized as an appropriate non-invasive therapeutic modality since it can increase cognitive performance and modulate neural oscillations with little or no side effects. Therefore, our objective was to set up, in the sedated adult rat, a stimulation method that is able to normalize ketamine-induced increase in gamma-frequency (30–80 Hz) oscillations and decrease in sigma-frequency (10–17 Hz) oscillations. Unilateral and bipolar frontoparietal (FP), transcranial anodal stimulation by direct current (<+1 mA) was applied in ketamine-treated rats. A concomitant bilateral electroencephalographic recording of the parietal cortex measured the stimulation effects on its spontaneously occurring oscillations. A 5 min FP anodal tDCS immediately and quickly reduced, significantly with an intensity-effect relationship, the ketamine-induced gamma hyperactivity, and sigma hypoactivity at least in the bilateral parietal cortex. A duration effect was also recorded. The tDCS also tended to diminish the ketamine-induced delta hypoactivity. These preliminary neurophysiological findings are promising for developing a therapeutic proof-of-concept against neuropsychiatric disorders.
format	article
author	Lahogue Caroline Pinault Didier
author_facet	Lahogue Caroline Pinault Didier
author_sort	Lahogue Caroline
title	Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
title_short	Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
title_full	Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
title_fullStr	Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
title_full_unstemmed	Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies
title_sort	frontoparietal anodal tdcs reduces ketamine-induced oscillopathies
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/11a4823102a4451ab759654be97623bc
work_keys_str_mv	AT lahoguecaroline frontoparietalanodaltdcsreducesketamineinducedoscillopathies AT pinaultdidier frontoparietalanodaltdcsreducesketamineinducedoscillopathies
_version_	1718371402164207616

Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies

Ejemplares similares