Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study

Background/Aim. The gold standard in treating the advanced ovarian cancer (AOC) is primary debulking surgery (PDS) followed by platinum-based adjuvant chemotherapy. In the AOC, the extent of tumor resection (residual tumor volume) is the most important prognostic factor for overall survival (OS) and...

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Autores principales:	Maričić Slobodan, Mandić Aljoša, Dejanović Ninoslav, Kladar Nebojša, Popović Marina, Ivković-Kapicl Tatjana, Gutić Bojana, Kokanov Dunja
Formato:	article
Lenguaje:	EN SR
Publicado:	Military Health Department, Ministry of Defance, Serbia 2021
Materias:	cytoreduction surgical procedures drug therapy gynecologic surgical procedures ovarian neoplasms survival prognosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/11a657e983c649b6b6b85e9fd0780bdc
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spelling	oai:doaj.org-article:11a657e983c649b6b6b85e9fd0780bdc2021-12-01T13:00:25ZNeoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study0042-84502406-072010.2298/VSP190110038Mhttps://doaj.org/article/11a657e983c649b6b6b85e9fd0780bdc2021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000038M.pdfhttps://doaj.org/toc/0042-8450https://doaj.org/toc/2406-0720Background/Aim. The gold standard in treating the advanced ovarian cancer (AOC) is primary debulking surgery (PDS) followed by platinum-based adjuvant chemotherapy. In the AOC, the extent of tumor resection (residual tumor volume) is the most important prognostic factor for overall survival (OS) and progression-free survival (PFS). Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is an experimental treatment of the AOC, introduced in clinical practice in order to improve cytoreduction rate and prolong survival. The aim of this study was to compare the survival and cytoreduction rate of NACT+IDS and PDS in patients with the AOC. Methods. This retrospective cohort study included patients with the AOC, separated into two groups. The first group treated with PDS had 59 patients, while the second group, treated with NACT + IDS, had 33 patients. Results. A lower rate of suboptimal cytoreduction (39.39%) was found in the NACT + IDS group than in the PDS group (57.63%). The percentage of complete cytoreduction was higher in patients treated with NACT + IDS (51.52%) than in those treated with PDS (38.98%). Nevertheless, median OS and PFS were not significantly different between the groups (p < 0.05). OS was 35 months and 31 months in the PDS and NACT + IDS groups, respectively. PFS was 16 months in the PDS and 19 months in the NACT + IDS group. Conclusion. Despite the higher rate of optimal debulking surgery after NACT+ IDS, survival of patients treated with method was not better than those treated with PDS. The decision for either NACT+IDS or PDS should be tailored to the individual patient.Maričić SlobodanMandić AljošaDejanović NinoslavKladar NebojšaPopović MarinaIvković-Kapicl TatjanaGutić BojanaKokanov DunjaMilitary Health Department, Ministry of Defance, Serbiaarticlecytoreduction surgical proceduresdrug therapygynecologic surgical proceduresovarian neoplasmssurvivalprognosisMedicine (General)R5-920ENSRVojnosanitetski Pregled, Vol 78, Iss 11, Pp 1193-1199 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	cytoreduction surgical procedures drug therapy gynecologic surgical procedures ovarian neoplasms survival prognosis Medicine (General) R5-920
spellingShingle	cytoreduction surgical procedures drug therapy gynecologic surgical procedures ovarian neoplasms survival prognosis Medicine (General) R5-920 Maričić Slobodan Mandić Aljoša Dejanović Ninoslav Kladar Nebojša Popović Marina Ivković-Kapicl Tatjana Gutić Bojana Kokanov Dunja Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
description	Background/Aim. The gold standard in treating the advanced ovarian cancer (AOC) is primary debulking surgery (PDS) followed by platinum-based adjuvant chemotherapy. In the AOC, the extent of tumor resection (residual tumor volume) is the most important prognostic factor for overall survival (OS) and progression-free survival (PFS). Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is an experimental treatment of the AOC, introduced in clinical practice in order to improve cytoreduction rate and prolong survival. The aim of this study was to compare the survival and cytoreduction rate of NACT+IDS and PDS in patients with the AOC. Methods. This retrospective cohort study included patients with the AOC, separated into two groups. The first group treated with PDS had 59 patients, while the second group, treated with NACT + IDS, had 33 patients. Results. A lower rate of suboptimal cytoreduction (39.39%) was found in the NACT + IDS group than in the PDS group (57.63%). The percentage of complete cytoreduction was higher in patients treated with NACT + IDS (51.52%) than in those treated with PDS (38.98%). Nevertheless, median OS and PFS were not significantly different between the groups (p < 0.05). OS was 35 months and 31 months in the PDS and NACT + IDS groups, respectively. PFS was 16 months in the PDS and 19 months in the NACT + IDS group. Conclusion. Despite the higher rate of optimal debulking surgery after NACT+ IDS, survival of patients treated with method was not better than those treated with PDS. The decision for either NACT+IDS or PDS should be tailored to the individual patient.
format	article
author	Maričić Slobodan Mandić Aljoša Dejanović Ninoslav Kladar Nebojša Popović Marina Ivković-Kapicl Tatjana Gutić Bojana Kokanov Dunja
author_facet	Maričić Slobodan Mandić Aljoša Dejanović Ninoslav Kladar Nebojša Popović Marina Ivković-Kapicl Tatjana Gutić Bojana Kokanov Dunja
author_sort	Maričić Slobodan
title	Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
title_short	Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
title_full	Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
title_fullStr	Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
title_full_unstemmed	Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
title_sort	neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study
publisher	Military Health Department, Ministry of Defance, Serbia
publishDate	2021
url	https://doaj.org/article/11a657e983c649b6b6b85e9fd0780bdc
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Neoadjuvant chemotherapy followed by interval debulking surgery versus primary debulking surgery in the advanced epithelial ovarian cancer- a retrospective cohort study

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