A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions

Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions.

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Autores principales:	Sebastian G. Wicha, Chunli Chen, Oskar Clewe, Ulrika S. H. Simonsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11acac90593d417596ce8ff040aeaa85
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spelling	oai:doaj.org-article:11acac90593d417596ce8ff040aeaa852021-12-02T14:40:22ZA general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions10.1038/s41467-017-01929-y2041-1723https://doaj.org/article/11acac90593d417596ce8ff040aeaa852017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01929-yhttps://doaj.org/toc/2041-1723Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions.Sebastian G. WichaChunli ChenOskar CleweUlrika S. H. SimonssonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian G. Wicha Chunli Chen Oskar Clewe Ulrika S. H. Simonsson A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
description	Assessment of pharmacodynamic interactions is at the heart of combination therapy development. Here the authors introduce a general drug interaction scoring model that enables quantification of synergistic and antagonistic interactions and determination of the directionality of the interactions.
format	article
author	Sebastian G. Wicha Chunli Chen Oskar Clewe Ulrika S. H. Simonsson
author_facet	Sebastian G. Wicha Chunli Chen Oskar Clewe Ulrika S. H. Simonsson
author_sort	Sebastian G. Wicha
title	A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
title_short	A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
title_full	A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
title_fullStr	A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
title_full_unstemmed	A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
title_sort	general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/11acac90593d417596ce8ff040aeaa85
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A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions

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