Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities
The incidences of traumatic brain injuries (TBIs) are increasing globally because of expanding population and increased dependencies on motorized vehicles and machines. This has resulted in increased socio-economic burden on the healthcare system, as TBIs are often associated with mental and physica...
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MDPI AG
2021
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oai:doaj.org-article:11adca7a32b240f49afe159156e8797b2021-11-11T16:48:10ZDynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities10.3390/ijms2221113131422-00671661-6596https://doaj.org/article/11adca7a32b240f49afe159156e8797b2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11313https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The incidences of traumatic brain injuries (TBIs) are increasing globally because of expanding population and increased dependencies on motorized vehicles and machines. This has resulted in increased socio-economic burden on the healthcare system, as TBIs are often associated with mental and physical morbidities with lifelong dependencies, and have severely limited therapeutic options. There is an emerging need to identify the molecular mechanisms orchestrating these injuries to life-long neurodegenerative disease and a therapeutic strategy to counter them. This review highlights the dynamics and role of choline-containing phospholipids during TBIs and how they can be used to evaluate the severity of injuries and later targeted to mitigate neuro-degradation, based on clinical and preclinical studies. Choline-based phospholipids are involved in maintaining the structural integrity of the neuronal/glial cell membranes and are simultaneously the essential component of various biochemical pathways, such as cholinergic neuronal transmission in the brain. Choline or its metabolite levels increase during acute and chronic phases of TBI because of excitotoxicity, ischemia and oxidative stress; this can serve as useful biomarker to predict the severity and prognosis of TBIs. Moreover, the effect of choline-replenishing agents as a post-TBI management strategy has been reviewed in clinical and preclinical studies. Overall, this review determines the theranostic potential of choline phospholipids and provides new insights in the management of TBI.Sana JavaidTalha FarooqZohabia RehmanAmmara AfzalWaseem AshrafMuhammad Fawad RasoolFaleh AlqahtaniSary AlsaneaFawaz AlasmariMohammed Mufadhe AlanaziMetab AlharbiImran ImranMDPI AGarticletraumatic brain injurycholinephosphatidylcholinebrain phospholipidsciticholinecholine-targeted therapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11313, p 11313 (2021) |
| institution |
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| collection |
DOAJ |
| language |
EN |
| topic |
traumatic brain injury choline phosphatidylcholine brain phospholipids citicholine choline-targeted therapy Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
traumatic brain injury choline phosphatidylcholine brain phospholipids citicholine choline-targeted therapy Biology (General) QH301-705.5 Chemistry QD1-999 Sana Javaid Talha Farooq Zohabia Rehman Ammara Afzal Waseem Ashraf Muhammad Fawad Rasool Faleh Alqahtani Sary Alsanea Fawaz Alasmari Mohammed Mufadhe Alanazi Metab Alharbi Imran Imran Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities |
| description |
The incidences of traumatic brain injuries (TBIs) are increasing globally because of expanding population and increased dependencies on motorized vehicles and machines. This has resulted in increased socio-economic burden on the healthcare system, as TBIs are often associated with mental and physical morbidities with lifelong dependencies, and have severely limited therapeutic options. There is an emerging need to identify the molecular mechanisms orchestrating these injuries to life-long neurodegenerative disease and a therapeutic strategy to counter them. This review highlights the dynamics and role of choline-containing phospholipids during TBIs and how they can be used to evaluate the severity of injuries and later targeted to mitigate neuro-degradation, based on clinical and preclinical studies. Choline-based phospholipids are involved in maintaining the structural integrity of the neuronal/glial cell membranes and are simultaneously the essential component of various biochemical pathways, such as cholinergic neuronal transmission in the brain. Choline or its metabolite levels increase during acute and chronic phases of TBI because of excitotoxicity, ischemia and oxidative stress; this can serve as useful biomarker to predict the severity and prognosis of TBIs. Moreover, the effect of choline-replenishing agents as a post-TBI management strategy has been reviewed in clinical and preclinical studies. Overall, this review determines the theranostic potential of choline phospholipids and provides new insights in the management of TBI. |
| format |
article |
| author |
Sana Javaid Talha Farooq Zohabia Rehman Ammara Afzal Waseem Ashraf Muhammad Fawad Rasool Faleh Alqahtani Sary Alsanea Fawaz Alasmari Mohammed Mufadhe Alanazi Metab Alharbi Imran Imran |
| author_facet |
Sana Javaid Talha Farooq Zohabia Rehman Ammara Afzal Waseem Ashraf Muhammad Fawad Rasool Faleh Alqahtani Sary Alsanea Fawaz Alasmari Mohammed Mufadhe Alanazi Metab Alharbi Imran Imran |
| author_sort |
Sana Javaid |
| title |
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities |
| title_short |
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities |
| title_full |
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities |
| title_fullStr |
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities |
| title_full_unstemmed |
Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities |
| title_sort |
dynamics of choline-containing phospholipids in traumatic brain injury and associated comorbidities |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/11adca7a32b240f49afe159156e8797b |
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