A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey

Treponemal infections can be blood-borne with great public health consequences. This study is aimed at comparatively describing the five-year (2013-2017) regional epidemiology of treponemal infection using pregnant women in the sentinel survey and apparently healthy blood donors as a proxy for the g...

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Autores principales:	Sylvester Yao Lokpo, Ellis Owusu-Dabo, John Gameli Deku, Verner Ndudiri Orish, Gideon Kye-Duodu, Francis Abeku Ussher, Thomas Boakye, Daniel Adigbli, Louis Selassie Ameke, William Klutse Fianko, Robert Adedze-Kpodo, Henry Komla Letsa, Worlanyo Tashie, Noble Selorm Gbormittah, Godsway Edem Kpene, James Osei-Yeboah
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/11aee04ed712405f8e27392da9debb23
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spelling	oai:doaj.org-article:11aee04ed712405f8e27392da9debb232021-11-22T01:10:56ZA Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey2314-614110.1155/2021/4462389https://doaj.org/article/11aee04ed712405f8e27392da9debb232021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4462389https://doaj.org/toc/2314-6141Treponemal infections can be blood-borne with great public health consequences. This study is aimed at comparatively describing the five-year (2013-2017) regional epidemiology of treponemal infection using pregnant women in the sentinel survey and apparently healthy blood donors as a proxy for the general population at four sentinel sites in the Volta and Oti Regions of Ghana. We analyzed retrospective data from 17,744 prospective blood donors aged 18 to 58 years and 7,817 pregnant women in a sentinel survey with ages from 15 to 49 years at Hohoe, Ho, Tongu, and Krachi West sentinel sites in the Volta and Oti Regions. Laboratory data extracted include variables such as age, gender, date of blood donation, and Treponema pallidum chromatographic immunoassay results from the blood banks of the four study sites. The five-year treponemal infection rate among the pregnant women in the sentinel survey and prospective blood donors was 0.79% and 2.38%, respectively. Site-specific infection rate for population-based/sentinel survey was 4.6%/1.1%, 2.0%/0.5%, 1.3%/1.1, and 1.2%/0.3% for Hohoe, Ho, Krachi West, and Tongu, respectively. Significant gender disparity in Treponemal infection rate exists with a male preponderance. The regional infection rate in the sentinel survey is lower compared to the general population. Therefore, the use of pregnant women as a proxy for population estimates could underestimate the burden in the study jurisdiction.Sylvester Yao LokpoEllis Owusu-DaboJohn Gameli DekuVerner Ndudiri OrishGideon Kye-DuoduFrancis Abeku UssherThomas BoakyeDaniel AdigbliLouis Selassie AmekeWilliam Klutse FiankoRobert Adedze-KpodoHenry Komla LetsaWorlanyo TashieNoble Selorm GbormittahGodsway Edem KpeneJames Osei-YeboahHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Sylvester Yao Lokpo Ellis Owusu-Dabo John Gameli Deku Verner Ndudiri Orish Gideon Kye-Duodu Francis Abeku Ussher Thomas Boakye Daniel Adigbli Louis Selassie Ameke William Klutse Fianko Robert Adedze-Kpodo Henry Komla Letsa Worlanyo Tashie Noble Selorm Gbormittah Godsway Edem Kpene James Osei-Yeboah A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey
description	Treponemal infections can be blood-borne with great public health consequences. This study is aimed at comparatively describing the five-year (2013-2017) regional epidemiology of treponemal infection using pregnant women in the sentinel survey and apparently healthy blood donors as a proxy for the general population at four sentinel sites in the Volta and Oti Regions of Ghana. We analyzed retrospective data from 17,744 prospective blood donors aged 18 to 58 years and 7,817 pregnant women in a sentinel survey with ages from 15 to 49 years at Hohoe, Ho, Tongu, and Krachi West sentinel sites in the Volta and Oti Regions. Laboratory data extracted include variables such as age, gender, date of blood donation, and Treponema pallidum chromatographic immunoassay results from the blood banks of the four study sites. The five-year treponemal infection rate among the pregnant women in the sentinel survey and prospective blood donors was 0.79% and 2.38%, respectively. Site-specific infection rate for population-based/sentinel survey was 4.6%/1.1%, 2.0%/0.5%, 1.3%/1.1, and 1.2%/0.3% for Hohoe, Ho, Krachi West, and Tongu, respectively. Significant gender disparity in Treponemal infection rate exists with a male preponderance. The regional infection rate in the sentinel survey is lower compared to the general population. Therefore, the use of pregnant women as a proxy for population estimates could underestimate the burden in the study jurisdiction.
format	article
author	Sylvester Yao Lokpo Ellis Owusu-Dabo John Gameli Deku Verner Ndudiri Orish Gideon Kye-Duodu Francis Abeku Ussher Thomas Boakye Daniel Adigbli Louis Selassie Ameke William Klutse Fianko Robert Adedze-Kpodo Henry Komla Letsa Worlanyo Tashie Noble Selorm Gbormittah Godsway Edem Kpene James Osei-Yeboah
author_facet	Sylvester Yao Lokpo Ellis Owusu-Dabo John Gameli Deku Verner Ndudiri Orish Gideon Kye-Duodu Francis Abeku Ussher Thomas Boakye Daniel Adigbli Louis Selassie Ameke William Klutse Fianko Robert Adedze-Kpodo Henry Komla Letsa Worlanyo Tashie Noble Selorm Gbormittah Godsway Edem Kpene James Osei-Yeboah
author_sort	Sylvester Yao Lokpo
title	A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey
title_short	A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey
title_full	A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey
title_fullStr	A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey
title_full_unstemmed	A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey
title_sort	comparative study of the epidemiology of treponemal infection in the volta and oti regions of ghana: a five-year multisite parallel population-based analysis vis-à-vis the sentinel survey
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/11aee04ed712405f8e27392da9debb23
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A Comparative Study of the Epidemiology of Treponemal Infection in the Volta and Oti Regions of Ghana: A Five-Year Multisite Parallel Population-Based Analysis vis-à-vis the Sentinel Survey

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